Evidence map›Paper›PMID 37790429›Full record

ArticleResearch square2023

Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI.

Jonathan J Molina, Kurt N Kohler, Christopher Gager, Marissa J Andersen, Ellsa Wongso, Elizabeth R Lucas, Andrew Paik, Wei Xu, Deborah L Donahue, Karla Bergeron and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Jonathan J MolinaIntegrated Biomedical Sciences, University of Notre Dame, IN 46556, USA.
Kurt N KohlerDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Christopher GagerDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Marissa J AndersenDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Ellsa WongsoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Elizabeth R LucasDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0009-0002-1478-9324
Andrew PaikDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0009-0004-5622-1096
Wei XuDepartment of Molecular Microbiology, Washington University School of Medicine, MO 63110, USA.ORCID 0000-0003-4319-7432
Deborah L DonahueW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Karla BergeronDepartment of Surgery, Washington University School of Medicine, MO 63110, USA.
Aleksandra KlimDepartment of Surgery, Washington University School of Medicine, MO 63110, USA.
Michael G CaparonDepartment of Molecular Microbiology, Washington University School of Medicine, MO 63110, USA.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, MO 63110, USA.ORCID 0000-0001-8785-564X
Alana DesaiDepartment of Surgery, Washington University School of Medicine, MO 63110, USA.
Victoria A PloplisW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Matthew J FlickDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Francis J CastellinoW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA.
Ana L Flores-MirelesIntegrated Biomedical Sciences, University of Notre Dame, IN 46556, USA.ORCID 0000-0003-4610-4246
University of Notre Dame · USInstitute for Women's Policy Research · USWashington University in St. Louis · USUniversity of Washington · US

Funding

Rational design and synthesis of small molecule inhibitors targeting unique pathogenic mechanisms in Gram- and Gram+ bacteria important in UTIU19AI157797 · NIAID · WASHINGTON UNIVERSITY · PI ELLEBEDY, ALI HASSAN · 2021 to 2025
$11.4M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Targeting the Plasminogen Activation System to Limit Pancreatic Cancer Progression and Associated ThrombosisU01HL143403 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHEL, MELISSA L., FLICK, MATTHEW J. · 2018 to 2022
$4.2M
Mechanisms linking the plasminogen/fibrinogen axis to the pathogenesis of COVID-19R01HL160046 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLICK, MATTHEW J., GRALINSKI, LISA · 2021 to 2024
$2.2M
Understanding the role of catheter-associated protein deposition in the development of CAUTIR01DK128805 · NIDDK · UNIVERSITY OF NOTRE DAME · PI FLORES-MIRELES, ANA LIDIA, HOWELL, CAITLIN L · 2021 to 2025
$1.9M
Novel Therapeutic Approach to Invasive Group A Streptococcal DiseaseR21AI163825 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2022 to 2023
$432k
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R01 HL160046NHLBI NIH HHS U01 HL143403NIAID NIH HHS R21 AI163825NIAID NIH HHS U19 AI157797NIDDK NIH HHS R01 DK051406NIDDK NIH HHS R01 DK128805
6 · The paper itself

Abstract

Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat due to multi-drug resistance development among the CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens. Using our established mouse model of CAUTI, we identified that host populations exhibiting either genetic or acquired fibrinolytic-deficiencies, inducing fibrin deposition in the catheterized bladder, are predisposed to severe CAUTI and septicemia by diverse uropathogens in mono- and poly-microbial infections. Furthermore, we found that

Indexed as

bacterial proteasesC. albicansCAUTIdisseminationE. coliE. faecalisfibrin(ogen)fibrinolysisinflammationpolymicrobial

Identifiers

PMID37790429
PMCPMC10543281
OpenAlexW4386763811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.