Evidence map›Paper›PMID 37790423›Full record

ArticleResearch square2024

Protein restriction slows the development and progression of Alzheimer's disease in mice.

Reji Babygirija, Michelle M Sonsalla, Jericha Mill, Isabella James, Jessica H Han, Cara L Green, Mariah F Calubag, Gina Wade, Anna Tobon, John Michael and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 1 institution in 1 country.

Reji BabygirijaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Michelle M SonsallaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-8493-1416
Jericha MillDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Isabella JamesDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jessica H HanCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI.
Cara L GreenDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-2293-9364
Mariah F CalubagDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Gina WadeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Anna TobonDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
John MichaelDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Michaela M TrautmanDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Ryan MatoskaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Chung-Yang YehDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Isaac GrunowDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Heidi H PakDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-3287-6133
Michael J RigbyWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0001-8809-2648
Dominique A BaldwinDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Natalie M NiemiDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-5174-4005
John M DenuDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Luigi PuglielliDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-0259-8424
Judith SimcoxCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI.ORCID 0000-0001-7350-6342
Dudley W LammingDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-0079-4467
University of Wisconsin–Madison · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI James Alexander Fitzpatrick · 2013 to 2026
$27.1M
Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
Spastic paraplegia, neurodegeneration and autism: possible role for AT- 1/SLC33A1?R01NS094154 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Luigi Puglielli · 2015 to 2026
$4.3M
Creating a region- specific biomolecular atlas of the brain of Alzheimer’s diseaseR01AG078794 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI, Luigi Puglielli · 2022 to 2026
$3.7M
The regulation of health and longevity by branched-chain amino acidsR01AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Dudley William Lamming · 2018 to 2026
$3.1M
University of Wisconsin Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Scholars ProgramK12HD101368 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BARROILHET, LISA M, BURNSIDE, ELIZABETH S · 2020 to 2023
$2.9M
Dynamics and molecular mechanisms linking metabolism and the epigenomeR35GM149279 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI JOHN M DENU · 2023 to 2026
$2.8M
The regulation of cancer and aging by methionineR01AG084156 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI VINCENT L. CRYNS, JOHN M DENU · 2023 to 2026
$2.5M
The regulation of health and longevity by branched-chain amino acidsRF1AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM · 2023 to 2023
$2.1M
Comparative analysis of geroprotective interventions in established and novel mouse models of Alzheimer's diseaseR01AG062328 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM, MERRINS, MATTHEW J. · 2018 to 2022
$2.0M
Safer mTOR inhibition for human geroprotectionU01AG081482 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Adam R Konopka, Dudley William Lamming · 2023 to 2026
$1.8M
Dietary regulation of the hepatic epigenomeR01DK125859 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M, LAMMING, DUDLEY WILLIAM · 2021 to 2023
$1.8M
BLRD VA I01 BX004031BLRD VA IS1 BX005524NIA NIH HHS F31 AG066311NIA NIH HHS F31 AG081115NIA NIH HHS F31 AG082504NIA NIH HHS F32 AG077916NIA NIH HHS R01 AG056771NIA NIH HHS R01 AG062328NIA NIH HHS R01 AG078794NIA NIH HHS R01 AG084156NIA NIH HHS R21 AG061635NIA NIH HHS R56 AG056771NIA NIH HHS RF1 AG056771NIA NIH HHS T32 AG000213NIA NIH HHS U01 AG081482NICHD NIH HHS K12 HD101368NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK125859NIDDK NIH HHS R01 DK133479NIGMS NIH HHS R01 GM148487NIGMS NIH HHS R35 GM149279NIGMS NIH HHS R35 GM151130NINDS NIH HHS R01 NS094154
6 · The paper itself

Abstract

Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and many independent groups of researchers have shown that dietary protein restriction (PR) extends the lifespan and healthspan of mice. Here, we examined the effect of PR on metabolic health and the development and progression of Alzheimer's disease (AD) in the 3xTg mouse model of AD. We found that PR has metabolic benefits for 3xTg mice and non-transgenic controls of both sexes, promoting leanness and glycemic control in 3xTg mice and rescuing the glucose intolerance of 3xTg females. We found that PR induces sex-specific alterations in circulating metabolites and in the brain metabolome and lipidome, downregulating sphingolipid subclasses including ceramides, glucosylceramides, and sphingomyelins in 3xTg females. Consumption of a PR diet starting at 6 months of age reduced AD pathology in conjunction with reduced mTORC1 activity, increased autophagy, and had cognitive benefits for 3xTg mice. Finally, PR improved the survival of 3xTg mice. Our results demonstrate that PR slows the progression of AD at molecular and pathological levels, preserves cognition in this mouse model of AD, and suggests that PR or pharmaceutical interventions that mimic the effects of this diet may hold promise as a treatment for AD.

Indexed as

3xTgAlzheimer’s diseaseautophagymTORC1protein restriction

Identifiers

PMID37790423
PMCPMC10543316
OpenAlexW4386688155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.