Evidence map›Paper›PMID 37790411›Full record

ArticlebioRxiv : the preprint server for biology2023

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants.

S John Calise, Audrey G O'Neill, Anika L Burrell, Miles S Dickinson, Josephine Molfino, Charlie Clarke, Joel Quispe, David Sokolov, Rubén M Buey, Justin M Kollman

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

S John CaliseDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Audrey G O'NeillDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Anika L BurrellDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Miles S DickinsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Josephine MolfinoDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Charlie ClarkeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Joel QuispeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
David SokolovDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Rubén M BueyMetabolic Engineering Group, Departamento de Microbiología y Genética, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain.
Justin M KollmanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
University of Washington · USUniversidad de Salamanca · ES

Funding

TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
The Structure and Function of Metabolic FilamentsR01GM118396 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M · 2016 to 2023
$2.9M
Structure and function of metabolic enzyme assembliesR35GM149542 · NIGMS · UNIVERSITY OF WASHINGTON · PI Justin M Kollman · 2023 to 2026
$2.2M
IMPDH structure and function in retinal degenerationR21EY031546 · NEI · UNIVERSITY OF WASHINGTON · PI BROCKERHOFF, SUSAN E, KOLLMAN, JUSTIN M · 2020 to 2021
$479k
IMPDH1 structure and function in the healthy and diseased retinaF31EY030732 · NEI · UNIVERSITY OF WASHINGTON · PI BURRELL, ANIKA LAUREN · 2019 to 2021
$116k
NEI NIH HHS F31 EY030732NEI NIH HHS R21 EY031546NIGMS NIH HHS R01 GM118396NIGMS NIH HHS R35 GM149542NIGMS NIH HHS T32 GM008268NIGMS NIH HHS T32 GM136534
6 · The paper itself

Abstract

Inosine monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in

Indexed as

filamentsIMPDHnucleotide metabolismphosphorylationretina

Identifiers

PMID37790411
PMCPMC10542554
OpenAlexW4386967032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.