Evidence map›Paper›PMID 37790404›Full record

ArticlebioRxiv : the preprint server for biology2024

Alternative splice variants of the mitochondrial fission protein

Zaineb Javed, Dong Hui Shin, Weihua Pan, Sierra R White, Yeon Soo Kim, Amal Taher Elhaw, Shriya Kamlapurkar, Ya-Yun Cheng, J Cory Benson, Ahmed Emam Abdelnaby and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 4 institutions in 1 country.

Zaineb JavedUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0003-1336-2564
Dong Hui ShinDepartment of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Weihua PanUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.
Sierra R WhiteDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0003-0764-9585
Yeon Soo KimDepartment of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Amal Taher ElhawUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0001-6547-3018
Shriya KamlapurkarUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0002-2686-3387
Ya-Yun ChengUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0002-2472-0577
J Cory BensonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA, USA.
Ahmed Emam AbdelnabyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA, USA.
Rébécca PhaëtonDepartment of Obstetrics & Gynecology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Hong-Gang WangDepartment of Pediatrics, College of Medicine, Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0003-0551-0571
Shengyu YangDepartment of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, PA, USA.ORCID 0000-0002-7933-6118
Mara L G SullivanCenter for Biologic Imaging, University of Pittsburgh School of Medicine, PA, USA; Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, USA.ORCID 0000-0003-3772-1998
Claudette M St CroixCenter for Biologic Imaging, University of Pittsburgh School of Medicine, PA, USA; Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, USA.
Simon C WatkinsCenter for Biologic Imaging, University of Pittsburgh School of Medicine, PA, USA; Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, USA.
Steven J MullettDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA, USA.
Stacy L GelhausDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0001-9083-6933
Nam LeeCenter for Biologic Imaging, University of Pittsburgh School of Medicine, PA, USA; Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, USA.
Lan G CoffmanUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0002-3753-1652
Katherine M AirdUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0002-5828-2325
Mohamed TrebakUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0001-6759-864X
Karthikeyan MythreyeDepartment of Pathology and O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5478-0098
Vonn WalterDepartment of Public Health Sciences, Division of Biostatistics and Bioinformatics and Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0001-6114-6714
Nadine HempelUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0002-5574-8783
Pennsylvania State University · USUniversity of Pittsburgh · USUniversity of Arizona · USUniversity of Alabama at Birmingham · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Project 3: Hedgehog Inhibition to Enhance Response to ICI TherapyP50CA272218 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRANCESMARY MODUGNO · 2023 to 2026
$11.0M
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Translational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0M
Role of Sox2 in Stress Adaptations to Ovarian Cancer Anchorage IndependenceR01CA230628 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEMPEL, NADINE, KARTHIKEYAN, MYTHREYE · 2019 to 2023
$2.1M
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancerR01CA242021 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEMPEL, NADINE · 2020 to 2024
$1.8M
An Exploris 240 for MetabolomicsS10OD032141 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2022 to 2022
$600k
Bringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594k
JEOL JEM-1011 TRANSMISSION ELECTRON MICROSCOPE: MUSCULAR DYSTROPHYS10RR019003 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2004 to 2004
$337k
Request for Ultracryomicrotomy equipmentS10RR025488 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2009 to 2009
$179k
NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA272218NCI NIH HHS R01 CA230628NCI NIH HHS R01 CA242021NCRR NIH HHS S10 RR019003NCRR NIH HHS S10 RR025488NHLBI NIH HHS R35 HL150778NHLBI NIH HHS T32 HL110849NIH HHS S10 OD023402NIH HHS S10 OD032141
6 · The paper itself

Abstract

Aberrant mitochondrial fission/fusion dynamics have been reported in cancer cells. While post translational modifications are known regulators of the mitochondrial fission/fusion machinery, we show that alternative splice variants of the fission protein Drp1 (

Identifiers

PMID37790404
PMCPMC10542115
OpenAlexW4386931362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.