ArticleResearch square2023
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade.
Geoffrey J Markowitz, Yi Ban, Diamile A Tavarez, Liron Yoffe, Enrique Podaza, Yongfeng He, Mitchell T Martin, Michael J P Crowley, Tito A Sandoval, Dingcheng Gao and 6 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors at 1 institution in 1 country.
Geoffrey J MarkowitzWeill Cornell Medicine.
Yi BanWeill Cornell Medicine.
Diamile A TavarezWeill Cornell Medicine.
Liron YoffeWeill Cornell Medicine.
Enrique PodazaWeill Cornell Medicine.
Yongfeng HeWeill Cornell Medicine.
Mitchell T MartinWeill Cornell Medicine.
Michael J P CrowleyWeill Cornell Medicine.
Tito A SandovalWeill Cornell Medicine.
Dingcheng GaoWeill Cornell Medicine.
M Laura MartinWeill Cornell Medicine.
Olivier ElementoWeill Cornell Medicine.
Juan R Cubillos-RuizWeill Cornell Medicine.
Timothy E McGrawWeill Cornell Medicine.
Nasser K AltorkiWeill Cornell Medicine.
Vivek MittalWeill Cornell Medicine.
Cornell University · US
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MDisparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2MInstitutional Career Development CoreKL2TR002385 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI YUAN-SHAN ZHU · 2017 to 2026
$13.3MMolecular and Translational Oncology ResearchT32CA203702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLENIS, JOHN, GIANNAKAKOU, PARASKEVI · 2017 to 2021
$1.4MNCATS NIH HHS KL2 TR002385NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NCI NIH HHS T32 CA203702
6 · The paper itselfAbstract
Indexed as
CD8+ T cellImmunotherapymetabolic reprogramingNon-small cell lung cancerpentose phosphate pathwayPKM2TCF1
Identifiers
PMID37790365
PMCPMC10543315
OpenAlexW4386880484
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390