Evidence map›Paper›PMID 37790363›Full record

ArticlebioRxiv : the preprint server for biology2023

Radial glia promote microglial development through integrin α

Gabriel L McKinsey, Nicolas Santander, Xiaoming Zhang, Kilian Kleemann, Lauren Tran, Aditya Katewa, Kaylynn Conant, Matthew Barraza, Kian Waddell, Carlos Lizama and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Gabriel L McKinseyUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Nicolas SantanderInstituto de Ciencias de la Salud, Universidad de ÓHiggins, Rancagua, Chile.
Xiaoming ZhangAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kilian KleemannAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren TranUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Aditya KatewaUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Kaylynn ConantUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Matthew BarrazaNorthwestern University, Department of Neuroscience, Chicago, IL, USA.
Kian WaddellUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Carlos LizamaUniversity of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA.
Marie La RussaStanford University, Department of Bioengineering, Stanford, CA, USA.
Hyun Ji KooUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Hyunji LeeUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Dibyanti MukherjeeUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
Helena PaidassiCIRI Centre International de Recherche en Infectiologie, Univ Lyon Inserm U1111 Université Claude Bernard Lyon 1 CNRS UMR5308 ENS de Lyon F-69007 Lyon France.
E S AntonUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kamran AtabaiUniversity of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA.
Dean SheppardUniversity of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA.
Oleg ButovskyAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thomas D ArnoldUniversity of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.
University of California, San Francisco · USBrigham and Women's Hospital · USNorthwestern University · USStanford University · USUniversité Claude Bernard Lyon 1 · FRUniversity of North Carolina at Chapel Hill · USUniversity of O'Higgins · CL

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7M
Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8M
DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITYR35NS116859 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVA S ANTON · 2020 to 2026
$4.1M
Primary Cilia: A Novel Signaling Gateway To Neural Circuit ModulationR01MH132710 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, LICHTMAN, JEFF W · 2022 to 2024
$3.3M
Defective heme transport in the development of congenital hydrocephalusR01NS123168 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD, THOMAS DARMODY · 2021 to 2025
$3.1M
How do CNS fibroblasts regulate the response to neuroinflammation?R01NS119615 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DANEMAN, RICHARD · 2021 to 2025
$2.4M
NCI NIH HHS P30 CA082103NEI NIH HHS P30 EY002162NIMH NIH HHS R01 MH132710NINDS NIH HHS R01 NS119615NINDS NIH HHS R01 NS123168NINDS NIH HHS R35 NS116859
6 · The paper itself

Abstract

Microglia diversity emerges from interactions between intrinsic genetic programs and environment-derived signals, but how these processes unfold and interact in the developing brain remains unclear. Here, we show that radial glia-expressed integrin beta 8 (ITGB8) expressed in radial glia progenitors activates microglia-expressed TGFβ1, permitting microglial development. Domain-restricted deletion of

Indexed as

developmentdifferentiationhomeostasisintegrin αVβ8Microglianeuroinflammationradial gliastem cellsTGFb signaling

Identifiers

PMID37790363
PMCPMC10542141
OpenAlexW4384342346

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.