Evidence map›Paper›PMID 37790347›Full record

ArticlebioRxiv : the preprint server for biology2023

Target-based discovery of a broad spectrum flukicide.

Daniel J Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M Rohr, Evgeny G Chulkov, Emery Smith, Louis Scampavia, Timothy P Spicer, Simone Haeberlein and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Daniel J SpragueDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sang-Kyu ParkDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Svenja GrambergBFS, Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.
Lisa BauerBFS, Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.
Claudia M RohrDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Evgeny G ChulkovDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Emery SmithUF Scripps Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA.
Louis ScampaviaUF Scripps Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA.
Timothy P SpicerUF Scripps Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA.
Simone HaeberleinBFS, Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Medical College of Wisconsin · USJustus-Liebig-Universität Gießen · DEScripps Research Institute · US

Funding

Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Identification of novel anthelmintics through a target-based screen of a parasite ion channelR01AI155405 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MARCHANT, JONATHAN S, SCAMPAVIA, LOUIS DANIEL · 2021 to 2024
$2.4M
Integrated Acoustic Transfer System for HTS Library ManagementS10OD025279 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2018 to 2018
$624k
Tandem Multi-modal Plate Readers for a High Throughput Screening platformS10OD030330 · OD · UNIVERSITY OF FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2021 to 2021
$600k
HTS Drug  Discovery DispensersS10OD026857 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2019 to 2019
$452k
MaxCyte Scalable Transfection SystemS10OD032248 · OD · UNIVERSITY OF FLORIDA · PI SPICER, TIMOTHY PATRICK · 2022 to 2022
$105k
NHLBI NIH HHS T32 HL134643NIAID NIH HHS R01 AI155405NIH HHS S10 OD025279NIH HHS S10 OD026857NIH HHS S10 OD030330NIH HHS S10 OD032248
6 · The paper itself

Abstract

Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases - for example, the parasitic blood fluke infection, schistosomiasis - are treated with the drug praziquantel (PZQ). However, PZQ is ineffective against disease caused by liver flukes from the genus

Indexed as

Ca2+ signalingparasitepraziquanteltransient receptor potential channel

Identifiers

PMID37790347
PMCPMC10542552
OpenAlexW4386982483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.