Evidence map›Paper›PMID 37790325›Full record

ArticlebioRxiv : the preprint server for biology2023

Increased LPS-Induced Fever and Sickness Behavior in Adult Male and Female Rats Perinatally Exposed to Morphine.

Hannah J Harder, Morgan G Gomez, Christopher T Searles, Meghan E Vogt, Anne Z Murphy

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hannah J HarderNeuroscience Institute, Georgia State University, 100 Piedmont Ave., Atlanta, GA, 30303.
Morgan G GomezNeuroscience Institute, Georgia State University, 100 Piedmont Ave., Atlanta, GA, 30303.
Christopher T SearlesNeuroscience Institute, Georgia State University, 100 Piedmont Ave., Atlanta, GA, 30303.
Meghan E VogtNeuroscience Institute, Georgia State University, 100 Piedmont Ave., Atlanta, GA, 30303.
Anne Z MurphyNeuroscience Institute, Georgia State University, 100 Piedmont Ave., Atlanta, GA, 30303.
Georgia State University · US

Funding

Impact of advanced age on opiate analgesiaR01DA041529 · NIDA · GEORGIA STATE UNIVERSITY · PI MURPHY, ANNE Z · 2017 to 2021
$1.8M
NIDA NIH HHS R01 DA041529
6 · The paper itself

Abstract

As a result of the current opioid crisis, the rate of children born exposed to opioids has skyrocketed. Later in life, these children have an increased risk for hospitalization and infection, raising concerns about potential immunocompromise, as is common with chronic opioid use. Opioids can act directly on immune cells or indirectly via the central nervous system to decrease immune system activity, leading to increased susceptibility, morbidity, and mortality to infection. However, it is currently unknown how perinatal opioid exposure (POE) alters immune function. Using a clinically relevant and translatable model of POE, we have investigated how baseline immune function and the reaction to an immune stimulator, lipopolysaccharide, is influenced by

Indexed as

immunityin uterolipopolysaccharidemicrogliamorphineperinatal

Identifiers

PMID37790325
PMCPMC10542495
OpenAlexW4386946056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.