Evidence map›Paper›PMID 37790321›Full record

ArticlebioRxiv : the preprint server for biology2023

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.

Beth L Dumont, Daniel Gatti, Mallory A Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J Sheehan, Taichi A Suzuki, Lydia K Wooldridge, Hilda Opoku Frempong, Gary Churchill and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Beth L DumontThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Daniel GattiThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Mallory A BallingerDepartment of Integrative Biology, Center for Computational Biology, and Museum of Vertebrate Zoology, University of California, Berkeley, Berkeley, CA 94720, USA.
Dana LinDepartment of Integrative Biology, Center for Computational Biology, and Museum of Vertebrate Zoology, University of California, Berkeley, Berkeley, CA 94720, USA.
Megan Phifer-RixeyDepartment of Biology, Drexel University, Philadelphia, PA 19104, USA.
Michael J SheehanDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.
Taichi A SuzukiCollege of Health Solutions and Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, USA 85281.
Lydia K WooldridgeThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Hilda Opoku FrempongThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Gary ChurchillThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Cathleen LutzThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Nadia RosenthalThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Jacqueline K WhiteThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Michael W NachmanDepartment of Integrative Biology, Center for Computational Biology, and Museum of Vertebrate Zoology, University of California, Berkeley, Berkeley, CA 94720, USA.

Funding

Use for ResourceP40OD011102 · OD · JACKSON LABORATORY · PI Steven Carmen Munger, Stephen A Murray · 2012 to 2026
$15.0M
Population genomics in laboratory and outbred mouse populationsR35GM133415 · NIGMS · JACKSON LABORATORY · PI BETHANY L DUMONT · 2019 to 2026
$3.1M
Natural selection and DNA sequence variation in MusR01GM074245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NACHMAN, MICHAEL W. · 2005 to 2015
$3.0M
The genomic basis of environmental adaptation in house miceR35GM149304 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MICHAEL W. NACHMAN · 2023 to 2026
$1.6M
The genomic basis of environmental adaptation in miceR01GM127468 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NACHMAN, MICHAEL W. · 2018 to 2021
$1.3M
NIGMS NIH HHS R01 GM074245NIGMS NIH HHS R01 GM127468NIGMS NIH HHS R35 GM133415NIGMS NIH HHS R35 GM149304NIH HHS P40 OD011102
6 · The paper itself

Abstract

The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations for a century. However, laboratory mice capture a narrow subset of the genetic variation found in wild mouse populations. This consideration inherently restricts the scope of potential discovery in laboratory models and narrows the pool of potentially identified phenotype-associated variants and pathways. Wild mouse populations are reservoirs of predicted functional and disease-associated alleles, but the sparsity of commercially available, well-characterized wild mouse strains limits their broader adoption in biomedical research. To overcome this barrier, we have recently imported, sequenced, and phenotyped a set of 11 wild-derived inbred strains developed from wild-caught

Identifiers

PMID37790321
PMCPMC10542534

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.