A novel "off-on" fluorescent probe for the detection of nickel ions and its clinical application.

Hua-Wei Yi, Xian-Mo Wang, Jia-Hao Wu, Chang-Li Zhang, Yi-Di Ding

Open access · goldAbstract read

In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.7field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hua-Wei YiLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.

Xian-Mo WangLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.

Jia-Hao WuLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.

Chang-Li ZhangDepartment of Pharmacy, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.

Yi-Di DingDepartment of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.

First People's Hospital of Jingzhou · CNYangtze University · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nickel serves as an essential micronutrient for the human body, playing a vital role in various enzymatic processes. However, excessive nickel entering the environment can cause pollution and pose serious risks to animals, plants, and human health. High concentrations of nickel ions in the human body increase the risk of various diseases, highlighting the need for accurate measurement of nickel ions levels. In this study, we designed a sequence-specific cleavage probe for nickel (II) ion called SSC-Ni. Similar to the TaqMan probe, SSC-Ni is an off-on fluorescent probe with an exceptionally low background fluorescence signal. It exhibits high detection specificity, making it highly selective for nickel ions, and the detection limit of the probe towards Ni

Indexed as

clinical applicationfluorescent probenickel ionsoff-on fluorescent probesequence-specific cleavage

Identifiers

PMID37790258

DOI10.3389/fbioe.2023.1261178

PMCPMC10544904

OpenAlexW4386849958

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.