Evidence map›Paper›PMID 37789643›Full record

ArticleCNS neuroscience & therapeutics2024

Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury.

Yabin Ji, Yiman Chen, Xixi Tan, Xiaowen Huang, Qiang Gao, Yinzhong Ma, Shilun Yang, Meifang Yin, Min Yu, Cheng Fang and 3 more

Open access · goldAbstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Yabin JiDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yiman ChenDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xixi TanDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaowen HuangInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Qiang GaoInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yinzhong MaInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Shilun YangInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0003-2734-3698
Meifang YinInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Min YuInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Cheng FangInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yu WangState Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Zhu ShiDepartment of Neurology, 10th Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, China.ORCID 0000-0002-6677-3271
Junlei ChangInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0002-0319-9022
Chinese Academy of Sciences · CNDongguan People’s Hospital · CNPharmaceutical Biotechnology (Czechia) · CZ

Funding

Guangdong Province Basic and Applied Basic Research GrantInternational collaboration project of Chinese Academy of SciencesNational Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaPresident Foundation of Nanfang HospitalScience Technology and Innovation Commission of Shenzhen Municipality
6 · The paper itself

Abstract

backgroundReperfusion therapy after ischemic stroke often causes brain microvascular injury. However, the underlying mechanisms are unclear.

methodsTranscriptomic and proteomic analyses were performed on human cerebral microvascular endothelial cells following oxygen-glucose deprivation (OGD) or OGD plus recovery (OGD/R) to identify molecules and signaling pathways dysregulated by reperfusion. Major findings were further validated in a mouse model of cerebral ischemia and reperfusion.

resultsTranscriptomic analysis identified 390 differentially expressed genes (DEGs) between the OGD/R and OGD group. Pathway analysis indicated that these genes were mostly associated with inflammation, including the TNF signaling pathway, TGF-β signaling pathway, cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, and NF-κB signaling pathway. Proteomic analysis identified 201 differentially expressed proteins (DEPs), which were primarily associated with extracellular matrix destruction and remodeling, impairment of endothelial transport function, and inflammatory responses. Six genes (DUSP1, JUNB, NFKBIA, NR4A1, SERPINE1, and THBS1) were upregulated by OGD/R at both the mRNA and protein levels. In mice with cerebral ischemia and reperfusion, brain TNF signaling pathway was activated by reperfusion, and inhibiting TNF-α with adalimumab significantly attenuated reperfusion-induced brain endothelial inflammation. In addition, the protein level of THBS1 was substantially upregulated upon reperfusion in brain endothelial cells and the peri-endothelial area in mice receiving cerebral ischemia.

conclusionOur study reveals the key molecular signatures of brain endothelial reperfusion injury and provides potential therapeutic targets for the treatment of brain microvascular injury after reperfusion therapy in ischemic stroke.

Indexed as

Brain InjuriesBrain IschemiaIschemic StrokeReperfusion InjuryAnimalsBrainEndothelial CellsGene Expression ProfilingGlucoseHumansInflammationMiceOxygenProteomicsReperfusionGlucoseOxygenblood–brain barrierinflammationischemic strokemulti‐omicsreperfusion injury

Identifiers

PMID37789643
PMCPMC11017417
OpenAlexW4387327187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.