Evidence map›Paper›PMID 37789630›Full record

SynthesisThe journal of international advanced otology2023

Cataloging Existing Hearing Loss Cohort Data to Guide the Development of Precision Medicine for Sensorineural Hearing Loss: A Systematic Review of Hearing Repositories.

Priya Sethukumar, Rishi Mandavia, Omursen Yildirim, Georgina Hazell, Haran Devakumar, Muhammad Ahmed, Emilien Stragier, Marie Josée Duran, Anne G M Schilder, Nishchay Mehta

Open access · diamondAbstract readSystematic Review
In one paragraph

Synthesis in The journal of international advanced otology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Priya SethukumarNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, UK.
Rishi MandaviaNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, UK.
Omursen YildirimNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, UK.
Georgina HazellNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; Royal Surrey NHS Foundation Trust, Surrey, UK.
Haran DevakumarNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; North Middlesex University Hospital Trust, London, UK.
Muhammad AhmedNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; University of Leeds School of Medicine, Leeds, UK.
Emilien StragierFondation Pour l'Audition, Paris, France.
Marie Josée DuranFondation Pour l'Audition, Paris, France.
Anne G M SchilderNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, UK.
Nishchay MehtaNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, UK; evidENT, Ear Institute, University College London, UK; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, UK.
University College London Hospitals NHS Foundation Trust · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent breakthroughs in our understanding of sensorineural hearing loss etiology have encouraged the identification of novel hearing therapeutics, paving the way for precision hearing medicine. Critical to this field is the curation of health resources on hearing data. A systematic review of the literature was conducted to map existing (inter)national and regional datasets that include hearing data to inform the development of future hearing repositories. Systematic literature review was performed adhering to Preferred Reporting Items for Systematic Review and MetaAnalysis recommendations. Databases, including those from gray literature, were searched to identify publications reporting on phenotypic and/ or genotypic hearing data in May 2019. The databases reviewed were Medline, PubMed, Embase databases, and Google Scholar. Publications on local datasets were excluded. All hearing datasets identified in the screening process were noted. For each dataset, geography, context, objective, period of time run, numbers and demographics of participants, genomic data, hearing measures and instruments used were extracted and cataloged. One hundred and eighty-eight datasets were identified, containing hearing data on populations ranging from 100 to 1.39 million individuals, and all extracted data have been cataloged. This searchable resource has been made accessible online. This unique catalog provides an overview of existing datasets that contain valuable information on hearing. This can be used to inform the development of national and international patient data repositories for hearing loss and guide strategic collaboration between key stakeholder groups, pivotal to the delivery and development of sensorineural hearing loss precision diagnostics and treatments.

Indexed as

DeafnessHearing LossHearing Loss, SensorineuralHearingHumansPrecision Medicine

Identifiers

PMID37789630
PMCPMC10645189
OpenAlexW4387260540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.