Evidence map›Paper›PMID 37789461›Full record

ArticleTrials2023

Delirium and neuropsychological recovery among emergency general surgery survivors (DANE): study protocol for a randomized controlled trial and collaborative care intervention.

Sanjay Mohanty, Emma Holler, Damaris Ortiz, Ashley Meagher, Anthony Perkins, Peggy Bylund, Babar Khan, Frederick Unverzagt, Hupuing Xu, Angela Ingraham and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05373017 (Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05373017 naactive not recruitingnot on this map

Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors (DANE)

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2023 to 2027Enrolled528ConditionsDeliriumArmsDANE Recovery Program, Questionnaires
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sanjay MohantyIndiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0295-3457
Emma HollerIndiana University School of Medicine, Indianapolis, IN, USA.
Damaris OrtizIndiana University School of Medicine, Indianapolis, IN, USA.
Ashley MeagherIndiana University School of Medicine, Indianapolis, IN, USA.
Anthony PerkinsIndiana University School of Medicine, Indianapolis, IN, USA.
Peggy BylundIndiana University Center for Aging Research, Regenstrief Institute, Inc, Indianapolis, IN, USA.
Babar KhanIndiana University School of Medicine, Indianapolis, IN, USA.
Frederick UnverzagtIndiana University School of Medicine, Indianapolis, IN, USA.
Hupuing XuIndiana University School of Medicine, Indianapolis, IN, USA.
Angela IngrahamDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Ave, Madison, G5/335, USA.
Malaz BoustaniIndiana University School of Medicine, Indianapolis, IN, USA.
Ben ZarzaurDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Ave, Madison, G5/335, USA. zarzaur@surgery.wisc.edu.
Indiana University School of MedicineRegenstrief Institute · USUniversity of Wisconsin–Madison · US

Funding

Emergency General Surgery Delirium Recovery Model: A Collaborative Care InterventionR01AG076489 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI MALAZ BOUSTANI, Ben L Zarzaur · 2022 to 2026
$10.2M
NIA NIH HHS 1R01AG076489-01NIA NIH HHS R01 AG076489
6 · The paper itself

Abstract

backgroundDelirium is a complex neuropsychiatric syndrome which consists of acute and varying changes in cognition and consciousness. Patients who develop delirium are at increased risk for a constellation of physical, cognitive, and psychological disabilities long after the delirium has ended. Collaborative care models integrating primary and specialty care in order to address patients with complex biopsychosocial needs have been demonstrated to improve outcomes in patients with chronic diseases. The purpose of this study is to evaluate the ability of a collaborative care model on the neuropsychologic recovery of delirium survivors following emergency surgery.

methodsThis protocol describes a multicenter (eight hospitals in three states) randomized controlled trial in which 528 patients who develop delirium following emergency surgery will be randomized to either a collaborative care model or usual care. The efficacy of the collaborative care model on cognitive, physical, and psychological recovery in these delirium survivors will then be evaluated over 18 months. DISCUSSION: This will be among the first randomized clinical trials in postoperative delirium survivors evaluating an intervention designed to mitigate the downstream effects of delirium and improve the neuropsychologic recovery after surgery. We hope that the results of this study will add to and inform strategies to improve postoperative recovery in this patient group.

trial registrationClinicalTrials.gov NCT05373017. Registered on May 12, 2022.

Indexed as

DeliriumCognitionConsciousnessHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicTreatment OutcomeEmergency general surgeryPostoperative delirium

Identifiers

PMID37789461
PMCPMC10548755
OpenAlexW4387306059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.