ArticleHuman genomics2023
Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis.
Article in Human genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- A study on metabolic differences between infectious and non-infectious stones in patients with urine culture positive for Proteus mirabilis.BMC urology · 2026Article
- Assessing causal associations of FGF23 and α-Klotho with urolithiasis using Mendelian randomization analysis.Urolithiasis · 2025Article
- Dietary patterns, physical activity, and risk of urinary tract diseases: a two sample Mendelian randomization analysis.American journal of clinical and experimental immunology · 2025Article
- Causal association of metabolic syndrome with chronic kidney disease progression: A Mendelian randomization study.Pediatric discovery · 2024Article
- Effects of multiple fluid intake on Urolithiasis by mendelian randomization study.Scientific reports · 2024Article
- Causal associations between 45 dietary intake habits and urolithiasis: insights from genetic studies.Translational andrology and urology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies have proposed that food intakes are associated with the risk of urolithiasis. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal effects of different food intakes on urolithiasis.
methodsIndependent genetic variants associated with different food intakes at a genome-wide significant level were selected from summary-level statistics of genome-wide association studies from the UK Biobank. The association of these instrumental variables with urolithiasis was studied in a cohort from FinnGen Consortium.
resultsAmong the 15 studied food intake exposures, tea intake (odds ratio [OR] = 0.433, 95% confidence interval [CI] = 0.281-0.667, p value = 1.470 × 10
conclusionsGenetically proxied fresh fruit intake is causally associated with a reduced risk of the calculus of kidney and ureter.
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