ArticleMolecular horticulture2022
A positive feedback regulatory loop, SA-AtNAP-SAG202/SARD1-ICS1-SA, in SA biosynthesis involved in leaf senescence but not defense response.
Article in Molecular horticulture, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 18 citations in OpenAlex.
- Exogenous ABA combined with cytokinin enhances drought resistance inFrontiers in plant science · 2026Article
- Genome-wide identification of NAC transcription factors in Acer paxii, and their expression dynamics during leaf aging.Genes & genomics · 2025Article
- Salicylic acid accumulation: emerging molecular players and novel perspectives on plant development and nutrition.Journal of experimental botany · 2025Review
- AcNAC10, regulated by AcTGA07, enhances kiwifruit resistance to Pseudomonas syringae pv. actinidiae via inhibiting jasmonic acid pathway.Molecular horticulture · 2025Article
- A novel mode of WRKY1 regulating PR1-mediated immune balance to defend against powdery mildew in apple.Molecular horticulture · 2025Article
- An insertion of transposon in DcNAP inverted its function in the ethylene pathway to delay petal senescence in carnation (Dianthus caryophyllus L.).Plant biotechnology journal · 2023Article
- The ABA-AtNAP-SAG113 PP2C module regulates leaf senescence by dephoshorylating SAG114 SnRK3.25 in Arabidopsis.Molecular horticulture · 2023Article
- Hypothesis: the subcellular senescence sequence of a mesophyll cell mirrors the cell origin and evolution.Molecular horticulture · 2022Article
- NAC transcription factor TgNAP promotes tulip petal senescence.Plant physiology · 2022Article
- Recent progresses in molecular postharvest biology.Molecular horticulture · 2022Article
- Recent advances in proteomics and metabolomics in plants.Molecular horticulture · 2022Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
Salicylic acid (SA) is an important plant hormone that regulates defense responses and leaf senescence. It is imperative to understand upstream factors that regulate genes of SA biosynthesis. SAG202/SARD1 is a key regulator for isochorismate synthase 1 (ICS1) induction and SA biosynthesis in defense responses. The regulatory mechanism of SA biosynthesis during leaf senescence is not well understood. Here we show that AtNAP, a senescence-specific NAC family transcription factor, directly regulates a senescence-associated gene named SAG202 as revealed in yeast one-hybrid and in planta assays. Inducible overexpreesion of AtNAP and SAG202 lead to high levels of SA and precocious senescence in leaves. Individual knockout mutants of sag202 and ics1 have markedly reduced SA levels and display a significantly delayed leaf senescence phenotype. Furthermore, SA positively feedback regulates AtNAP and SAG202. Our research has uncovered a unique positive feedback regulatory loop, SA-AtNAP-SAG202-ICS1-SA, that operates to control SA biosynthesis associated with leaf senescence but not defense response.
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