Evidence map›Paper›PMID 37789329›Full record

Trial reportBMC anesthesiology2023

Comparison of different ratios of propofol-ketamine admixture in rapid-sequence induction of anesthesia for emergency laparotomy: a randomized controlled trial.

Mona Elsherbiny, Ahmed Hasanin, Sahar Kasem, Mohamed Abouzeid, Maha Mostafa, Ahmed Fouad, Yaser Abdelwahab

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05166330 (Comparison of Different Ratios of Propofol-ketamine Admixture in Rapid-sequence Induction of Anesthesia for Emergency Laparotomy), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05166330 phase4unknown statusnot on this map

Comparison of Different Ratios of Propofol-ketamine Admixture in Rapid-sequence Induction of Anesthesia for Emergency Laparotomy: a Randomized Controlled Trial

TypeinterventionalSponsorKasr El Aini HospitalRan2021 to 2022Enrolled74ConditionsHypotension, Induction of AnesthesiaArmsKetofol equal ratio, Ketofol 1:3 ratio
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mona ElsherbinyAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed HasaninAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. ahmedmohamedhasanin@gmail.com.
Sahar KasemAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed AbouzeidAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Maha MostafaAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed FouadAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Yaser AbdelwahabAnesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to compare the hemodynamic effect of two ratios of propofol and ketamine (ketofol), namely 1:1 and 1:3 ratios, in rapid-sequence induction of anesthesia for emergency laparotomy.

methodsThis randomized controlled study included adult patients undergoing emergency laparotomy under general anesthesia. The patients were randomized to receive either ketofol ratio of 1:1 (n = 37) or ketofol ratio of 1:3 (n = 37). Hypotension (mean arterial pressure < 70 mmHg) was managed by 5-mcg norepinephrine. The primary outcome was total norepinephrine requirements during the postinduction period. Secondary outcomes included the incidence of postinduction hypotension, and the intubation condition (excellent, good, or poor).

resultsThirty-seven patients in the ketofol-1:1 and 35 patients in the ketofol 1:3 group were analyzed. The total norepinephrine requirement was less in the ketofol-1:1 group than in the ketofol-1:3 group, P-values: 0.043. The incidence of postinduction hypotension was less in the ketofol-1:1 group (4 [12%]) than in ketofol-1:3 group (12 [35%]), P-value 0.022. All the included patients had excellent intubation condition.

conclusionIn patients undergoing emergency laparotomy, the use of ketofol in 1:1 ratio for rapid-sequence induction of anesthesia was associated with less incidence of postinduction hypotension and vasopressor consumption in comparison to the 1:3 ratio with comparable intubation conditions. CLINICAL

trial registrationNCT05166330. URL: https://clinicaltrials.gov/ct2/show/NCT05166330 .

Indexed as

HypotensionKetaminePropofolAdultAnesthesia, GeneralAnesthetics, IntravenousHumansLaparotomyNorepinephrineAnesthetics, IntravenousKetamineNorepinephrinePropofolEmergencyHypotensionKetamineLaparotomyPropofolRapid-sequence induction and intubation

Identifiers

PMID37789329
PMCPMC10546635
OpenAlexW4387312352

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.