Evidence map›Paper›PMID 37789028›Full record

ArticleNature communications2023

Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress.

Ling Ye, Yuanlong Hou, Wanyu Hu, Hongmei Wang, Ruopeng Yang, Qihan Zhang, Qiaoli Feng, Xiao Zheng, Guangyu Yao, Haiping Hao

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Journal for immunotherapy of cancer · 2026
    Article
  10. Journal of the Endocrine Society · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
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  17. Article
  18. Article
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  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ling Ye *NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.ORCID http://orcid.org/0000-0002-2012-7266
Yuanlong Hou *State Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University, Nanjing, 210009, China.
Wanyu Hu *NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Hongmei WangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.ORCID http://orcid.org/0000-0003-3269-8063
Ruopeng YangNMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Qihan ZhangBreast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.ORCID http://orcid.org/0009-0001-4899-1056
Qiaoli FengBreast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.ORCID http://orcid.org/0000-0002-6662-3118
Xiao ZhengState Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University, Nanjing, 210009, China.ORCID http://orcid.org/0000-0002-3883-4372
Guangyu YaoBreast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. yaogy@smu.edu.cn.ORCID http://orcid.org/0000-0002-3406-7612
Haiping HaoState Key Laboratory of Natural Medicines, Jiangsu Province Key Laboratory of Drug Metabolism, China Pharmaceutical University, Nanjing, 210009, China. haipinghao@cpu.edu.cn.ORCID http://orcid.org/0000-0003-2522-7546
Nanfang Hospital · CNChina Pharmaceutical University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress is a known risk factor for breast cancer, yet the underlying mechanisms are unclear. This study explores the potential involvement of microbial and metabolic signals in chronic stress-promoted breast cancer progression, revealing that reduced abundances of Blautia and its metabolite acetate may contribute to this process. Treatment with Blautia and acetate increases antitumor responses of CD8

Indexed as

Breast NeoplasmsAnimalsCD8-Positive T-LymphocytesFemaleHumansMice

Identifiers

PMID37789028
PMCPMC10547687
OpenAlexW4387299443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.