ArticleNPJ biofilms and microbiomes2023
Microfluidic investigation of the impacts of flow fluctuations on the development of Pseudomonas putida biofilms.
Article in NPJ biofilms and microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- The biofilm detachment modes and mechanisms in porous media.Biodegradation · 2026Review
- Genomic and phenotypic characterization of indigenous violacein-producing Chromobacterium amazonense SAM215 from lake sediment in Bangladesh.Scientific reports · 2026Article
- Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Review
- Growing Algae in Biofilms: Principles and Emerging Opportunities.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Flagellum-driven motility enhancesApplied and environmental microbiology · 2025Article
- Microfluidics unveils role of gravity and shear stress on Pseudomonas fluorescens motility and biofilm growth.NPJ biofilms and microbiomes · 2025Article
- Modulation of biofilm growth by shear and fluctuations in turbulent environments.Scientific reports · 2025Article
- The Impact of Fluid Flow on Microbial Growth and Distribution in Food Processing Systems.Foods (Basel, Switzerland) · 2025Review
- The landscape of biofilm models for phage therapy: mimicking biofilms in diabetic foot ulcers using 3D models.Frontiers in microbiology · 2025Review
- Phenotypic memory in quorum sensing.PLoS computational biology · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilms play critical roles in wastewater treatment, bioremediation, and medical-device-related infections. Understanding the dynamics of biofilm formation and growth is essential for controlling and exploiting their properties. However, the majority of current studies have focused on the impact of steady flows on biofilm growth, while flow fluctuations are common in natural and engineered systems such as water pipes and blood vessels. Here, we reveal the effects of flow fluctuations on the development of Pseudomonas putida biofilms through systematic microfluidic experiments and the development of a theoretical model. Our experimental results showed that biofilm growth under fluctuating flow conditions followed three phases: lag, exponential, and fluctuation phases. In contrast, biofilm growth under steady-flow conditions followed four phases: lag, exponential, stationary, and decline phases. Furthermore, we demonstrated that low-frequency flow fluctuations promoted biofilm growth, while high-frequency fluctuations inhibited its development. We attributed the contradictory impacts of flow fluctuations on biofilm growth to the adjustment time (T
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