ArticleNature communications2023
An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
- Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.Synthetic and systems biotechnology · 2027Review
- Recent progress in microbial succinic acid production: integrating genome engineering and fermentation strategies.World journal of microbiology & biotechnology · 2026Review
- Sustainable Production of Succinic Acid through COChem & bio engineering · 2026Review
- A unifying equation for fermentation sustainability across the titer-rate-yield landscape.Nature communications · 2026Article
- Beyond petrochemicals: challenges and opportunities in industrial-scale biomanufacturing.Nature communications · 2026Review
- Engineering a robust cell-surface display platform in the multi-stress-tolerant yeast Issatchenkia orientalis.Applied microbiology and biotechnology · 2026Article
- Coupled succinic acid fermentation and biogas upgrading enabled by in situ product recovery.Biotechnology for biofuels and bioproducts · 2026Article
- Perspectives for Advancing Biotechnological Succinic Acid Production.Microbial biotechnology · 2026Review
- Combining multiplex metabolic engineering with adaptive evolution strategies for high-level succinic acid production inSynthetic and systems biotechnology · 2026Article
- Photoelectrocatalytic-microbial biohybrid for succinic acid synthesis.Nature communications · 2026Article
- Bio-based oxalic acid production in Issatchenkia orientalis enables sustainable rare earth recovery.Nature communications · 2026Article
- High yield production of 3-hydroxypropionic acid using Issatchenkia orientalis.Nature communications · 2026Article
- Prospecting technology and economic potential to produce bio-succinic acid: a review.Biotechnology reports (Amsterdam, Netherlands) · 2025Review
- Production of bio-based lactones as monomers for a circular polymer economy.Nature reviews. Chemistry · 2025Review
- Sustainable Triacetic Acid Lactone Production from Sugarcane by Fermentation and Crystallization.ACS sustainable chemistry & engineering · 2025Article
- Ecological factors that drive microbial communities in culturally diverse fermented foods.BMC microbiology · 2025Article
- Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis.Nature communications · 2025Article
- Longitudinal alterations of gut mycobiota during 2 years after COVID-19 and its correlation with pulmonary sequela.Microbiology spectrum · 2025Article
- Comprehensive evaluation of the capacities of microbial cell factories.Nature communications · 2025Article
- Transcriptional profiling reveals the effect of arginine on Actinobacillus succinogenes growth and fermentation.World journal of microbiology & biotechnology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial production of succinic acid (SA) at an industrially relevant scale has been hindered by high downstream processing costs arising from neutral pH fermentation for over three decades. Here, we metabolically engineer the acid-tolerant yeast Issatchenkia orientalis for SA production, attaining the highest titers in sugar-based media at low pH (pH 3) in fed-batch fermentations, i.e. 109.5 g/L in minimal medium and 104.6 g/L in sugarcane juice medium. We further perform batch fermentation using sugarcane juice medium in a pilot-scale fermenter (300×) and achieve 63.1 g/L of SA, which can be directly crystallized with a yield of 64.0%. Finally, we simulate an end-to-end low-pH SA production pipeline, and techno-economic analysis and life cycle assessment indicate our process is financially viable and can reduce greenhouse gas emissions by 34-90% relative to fossil-based production processes. We expect I. orientalis can serve as a general industrial platform for production of organic acids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.