Evidence map›Paper›PMID 37788940›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Hyperexcitability in the Olfactory Bulb and Impaired Fine Odor Discrimination in the

Praveen Kuruppath, Lin Xue, Frederic Pouille, Shelly T Jones, Nathan E Schoppa

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Behavioral and Prefrontal Circuit Deficits in a Newly DevelopedBiological psychiatry global open science · 2026
    Article
  3. Review
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  8. Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  9. Review
  10. Article
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  15. Review
  16. Haploinsufficiency ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Praveen KuruppathDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Lin XueDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Frederic PouilleDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Shelly T JonesDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Nathan E SchoppaDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 nathan.schoppa@cuanschutz.edu.ORCID 0000-0003-1175-1830
University of Colorado Anschutz Medical Campus · US

Funding

Mechanisms of olfactory signal processingR01DC006640 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SCHOPPA, NATHAN ERIC · 2005 to 2025
$6.8M
Biophysical mechanisms that contribute to multiple output channels in the olfactory bulbF31DC017350 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI JONES, SHELLY T · 2018 to 2019
$65k
NIDCD NIH HHS F31 DC017350NIDCD NIH HHS R01 DC006640
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the single most common monogenetic cause of autism spectrum disorders (ASDs) in humans. FXS is caused by loss of expression of the fragile X mental retardation protein (FMRP), an mRNA-binding protein encoded on the X chromosome involved in suppressing protein translation. Sensory processing deficits have been a major focus of studies of FXS in both humans and rodent models of FXS, but olfactory deficits remain poorly understood. Here, we conducted experiments in wild-type (WT) and

Indexed as

Fragile X SyndromeOlfactory BulbAnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1HumansMaleMiceMice, KnockoutOdorantsReproducibility of ResultsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1autism spectrum disordersfragile X syndromeinhibitionmitral cellodor discriminationolfactory

Identifiers

PMID37788940
PMCPMC10697393
OpenAlexW4387299972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.