ArticleArchives of disease in childhood. Fetal and neonatal edition2023
Factors associated with the increased incidence of necrotising enterocolitis in extremely preterm infants in Sweden between two population-based national cohorts (2004-2007 vs 2014-2016).
Article in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Nutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE).Italian journal of pediatrics · 2026Guideline
- Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants.JAMA network open · 2026Article
- Mortality and morbidity in very preterm infants in Switzerland spanning 16 years (2006-2021).BMJ paediatrics open · 2026Article
- Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects.Translational pediatrics · 2026Review
- Early enteral nutrition practices and their association with growth and necrotising enterocolitis in extremely preterm infants-A dual national cohort study.Pediatric research · 2026Article
- Bowel habits in preterm infants: Observations from the first 2 weeks of life.Journal of pediatric gastroenterology and nutrition · 2025Observational
- Early antibiotic exposure and the risk of necrotizing enterocolitis in preterm neonates: insights from a large multicenter cohort in China.Pediatric research · 2025Article
- Centralisation of extremely preterm births and decreased early postnatal mortality in Sweden, 2004-2007 versus 2014-2016.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Effect of chorioamnionitis on necrotizing enterocolitis in preterm infants: a multicenter cohort study.Frontiers in pediatrics · 2025Article
- Respiratory support and bronchopulmonary dysplasia in infants born at 22-26 weeks gestation in Sweden, 2004-2007 and 2014-2016.The European respiratory journal · 2025Article
- Observational
- Risk of neurodevelopmental impairment in Swedish preterm children treated for necrotizing enterocolitis: retrospective cohort study.BJS open · 2024Article
- Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification.BMJ paediatrics open · 2024Article
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16 authors at 8 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate potential risk factors behind the increased incidence of necrotising enterocolitis (NEC) in Swedish extremely preterm infants.
designRegistry data from two population-based national cohorts were studied. NEC diagnoses (Bell stage ≥II) were validated against hospital records. PATIENTS: All liveborn infants <27 weeks of gestation 2004-2007 (n=704) and 2014-2016 (n=895) in Sweden.
main outcome measuresNEC incidence.
resultsThe validation process resulted in a 28% reduction of NEC cases but still confirmed a higher NEC incidence in the later epoch compared with the earlier (73/895 (8.2%) vs 27/704 (3.8%), p=0.001), while the composite of NEC or death was lower (244/895 (27.3%) vs 229/704 (32.5%), p=0.022). In a multivariable Cox regression model, censored for mortality, there was no significant difference in early NEC (0-7 days of life) between epochs (HR=0.9 (95% CI 0.5 to 1.9), p=0.9), but being born in the later epoch remained an independent risk factor for late NEC (>7 days) (HR=2.7 (95% CI 1.5 to 5.0), p=0.001). In propensity score analysis, a significant epoch difference in NEC incidence (12% vs 2.8%, p<0.001) was observed only in the tertile of infants at highest risk of NEC, where the 28-day mortality was lower in the later epoch (35% vs 50%, p=0.001). More NEC cases were diagnosed with intramural gas in the later epoch (33/73 (45.2%) vs 6/26 (23.1%), p=0.047).
conclusionsThe increase in NEC incidence between epochs was limited to cases occurring after 7 days of life and was partly explained by increased survival in the most extremely preterm infants. Misclassification of NEC is common.
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