Evidence map›Paper›PMID 37788710›Full record

ReviewBiological research for nursing2024

Fatigue, Toll-Like Receptor 4, and Pro-Inflammatory Cytokines in Adults With Subarachnoid Hemorrhage: A 6-Month Longitudinal Study.

Eeeseung Byun, Susan M McCurry, Suyoung Kwon, Chi-Shan Tsai, Jeehye Jun, Theo K Bammler, Kyra J Becker, Hilaire J Thompson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological research for nursing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eeeseung ByunDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8917-7093
Susan M McCurryDepartment of Child, Family and Population Health Nursing, University of Washington, Seattle, WA, USA.
Suyoung KwonDepartment of Child, Family and Population Health Nursing, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3045-7055
Chi-Shan TsaiDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.
Jeehye JunRed Cross College of Nursing, Chung-Ang University, Seoul, Republic of Korea.ORCID 0000-0003-1353-7125
Theo K BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Kyra J BeckerDepartment of Neurology, University of Washington, Seattle, WA, USA.
Hilaire J ThompsonDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5472-478X

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Research Education and Training CoreP30AG059304 · NIA · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI SIMON, MELISSA A. · 2018 to 2022
$3.1M
Center for Innovation in Sleep Self-Management- Informatics CoreP30NR016585 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN, WARD, TERESA M · 2016 to 2020
$2.4M
Mechanisms of Symptoms in Subarachnoid Hemorrhage: Sleep Disturbance, Fatigue and Impaired CognitionK23NR017404 · NINR · UNIVERSITY OF WASHINGTON · PI BYUN, EEESEUNG · 2017 to 2019
$437k
NCATS NIH HHS UL1 TR000423NIA NIH HHS P30 AG059304NINR NIH HHS K23 NR017404NINR NIH HHS P30 NR016585
6 · The paper itself

Abstract

backgroundFatigue is prevalent in subarachnoid hemorrhage (SAH) survivors. Biological mechanisms underlying fatigue post-SAH are not clear. Inflammation may contribute to the development of fatigue. This study aimed to examine the associations between inflammatory markers and fatigue during the first 6 months post-SAH. Specific biomarkers examined included both early and concurrent expression of Toll-Like Receptor 4 (TLR4) messenger RNA (mRNA) and plasma concentrations of pro-inflammatory cytokines, Tumor Necrosis Factor-alpha (TNF-α), Interleukin (IL)1β, and IL6.

methodsWe conducted a 6-month longitudinal study with a convenience sample of 43 SAH survivors. We collected blood samples on days 2, 3, and 7 and 2, 3, and 6 months post-SAH to assess biomarkers. Fatigue was assessed by the PROMIS Fatigue Scale at 2, 3, and 6 months. Linear mixed models were used to test the associations between early (days 2, 3, and 7) and concurrent (2, 3, and 6 months) TLR4 mRNA expression (TagMan gene expression assays) and TNF-α, IL1β, and IL6 plasma concentrations (multiplex assays) and concurrent fatigue.

results28% of SAH survivors experienced fatigue during the first 6 months post-SAH. Fatigue levels in SAH survivors were higher than those of the U.S. population and consistent during the 6 months. Experience of fatigue during the 6 months post-SAH was associated with higher IL1β plasma concentrations on day 7 and IL1β, IL6, and TNF-α plasma concentrations during the 6 months post-SAH.

conclusionInflammation appears to underlie the development of fatigue in SAH survivors.

Indexed as

CytokinesSubarachnoid HemorrhageAdultBiomarkersFatigueHumansInflammationInterleukin-6Longitudinal StudiesRNA, MessengerToll-Like Receptor 4Tumor Necrosis Factor-alphaBiomarkersCytokinesInterleukin-6RNA, MessengerToll-Like Receptor 4Tumor Necrosis Factor-alphacytokinefatigueinflammationstrokesubarachnoid hemorrhagetoll-like receptor 4

Identifiers

PMID37788710
PMCPMC13632675

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.