Evidence map›Paper›PMID 37788684›Full record

ArticleNature2023

Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling.

Benxiang Zhang, Jiayan He, Yang Gao, Laura Levy, Martins S Oderinde, Maximilian D Palkowitz, T G Murali Dhar, Michael D Mandler, Michael R Collins, Daniel C Schmitt and 8 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Interfacial Science for Electrosynthesis.Current opinion in electrochemistry · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Benxiang Zhang *Department of Chemistry, Scripps Research, La Jolla, CA, USA.
Jiayan He *Department of Chemistry, Scripps Research, La Jolla, CA, USA.
Yang GaoDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Laura LevyDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0009-0002-5743-1197
Martins S OderindeDepartment of Discovery Synthesis, Bristol Myers Squibb Research & Early Development, Princeton, NJ, USA.
Maximilian D PalkowitzSmall Molecule Drug Discovery, Bristol Myers Squibb Research & Early Development, Cambridge, MA, USA.ORCID 0000-0002-3651-5175
T G Murali DharBristol Myers Squibb Research & Early Development, Princeton, NJ, USA.
Michael D MandlerBristol Myers Squibb Research & Early Development, Princeton, NJ, USA.ORCID 0000-0003-4681-7473
Michael R CollinsOncology Medicinal Chemistry Department, Pfizer Pharmaceuticals, San Diego, CA, USA.
Daniel C SchmittMedicine Design, Pfizer Worldwide Research and Development, Groton, CT, USA.
Philippe N BolducBiogen Inc., Cambridge, MA, USA.ORCID 0000-0001-8726-4364
TeYu ChenBiogen Inc., Cambridge, MA, USA.
Sebastian ClementsonResearch and Early Development, LEO Pharma A/S, Ballerup, Denmark.
Nadia Nasser PetersenResearch and Early Development, LEO Pharma A/S, Ballerup, Denmark.ORCID 0000-0002-8595-3497
Gabriele LaudadioDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0000-0002-2749-8393
Cheng BiDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0000-0002-9332-9918
Yu KawamataDepartment of Chemistry, Scripps Research, La Jolla, CA, USA. yukawama@scripps.edu.ORCID 0000-0002-5515-9612
Phil S BaranDepartment of Chemistry, Scripps Research, La Jolla, CA, USA. pbaran@scripps.edu.ORCID 0000-0001-9193-9053
Scripps Institution of Oceanography · USBristol-Myers Squibb (United States) · USBiogen (United States) · USLeo Pharma (Denmark) · DKScripps Research Institute · USEli Lilly (United States) · USPfizer (United States) · US

Funding

Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
NIGMS NIH HHS R35 GM118176
6 · The paper itself

Abstract

Modern retrosynthetic analysis in organic chemistry is based on the principle of polar relationships between functional groups to guide the design of synthetic routes

Indexed as

Biological ProductsChemistry Techniques, SyntheticDecarboxylationElectrochemistryElectrodesPharmaceutical PreparationsCarboxylic AcidsLigandsMetal NanoparticlesNickelOxidation-ReductionSilverBiological ProductsCarboxylic AcidsLigandsNickelPharmaceutical PreparationsSilver

Identifiers

PMID37788684
PMCPMC10754231
OpenAlexW4387307764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.