Evidence map›Paper›PMID 37788674›Full record

ArticleACS infectious diseases2023

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting

Tomayo Berida, Samuel R McKee, Shamba Chatterjee, Destinee L Manning, Wei Li, Pankaj Pandey, Siddharth Kaushal Tripathi, Yassin Mreyoud, Asya Smirnov, Robert J Doerksen and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Tomayo BeridaDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0002-3578-1033
Samuel R McKeeDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Shamba ChatterjeeDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0003-1415-6981
Destinee L ManningDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0001-7825-5896
Wei LiMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523, United States.
Pankaj PandeyNational Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0001-9128-8254
Siddharth Kaushal TripathiNational Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, United States.
Yassin MreyoudDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Asya SmirnovDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Robert J DoerksenDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0002-3789-1842
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523, United States.ORCID 0000-0002-9212-0258
Christian DuchoDepartment of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken 66123, Germany.ORCID 0000-0002-0629-9993
Christina L StallingsDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Sudeshna RoyDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0003-0237-4156
University of Mississippi · USColorado State University · USSaarland University · DE

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Pilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI WILLETT, KRISTINE L · 2018 to 2022
$5.3M
MmpL3 as a target for novel anti-TB agentsR01AI116525 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2015 to 2024
$5.3M
Target-based chemotherapeutics development against Mycobacterium tuberculosisR21AI142210 · NIAID · UNIVERSITY OF MISSISSIPPI · PI ROY, SUDESHNA · 2019 to 2020
$411k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI116525NIAID NIH HHS R21 AI142210NIGMS NIH HHS P20 GM130460NIGMS NIH HHS P30 GM122733
6 · The paper itself

Abstract

The rise in multidrug resistant tuberculosis cases underscores the urgent need to develop new treatment strategies for tuberculosis. Herein, we report the discovery and synthesis of a new series of compounds containing a 3-thio-1,2,4-triazole moiety that show inhibition of

Indexed as

Mycobacterium tuberculosisTuberculosisTuberculosis, Multidrug-ResistantAnimalsAntitubercular AgentsMammalsStructure-Activity RelationshipAntitubercular Agents1,2,4-triazole-3-thionesantitubercular agentsdrug-resistant TBMycobacterium tuberculosisnarrow-spectrum antibacterials

Identifiers

PMID37788674
PMCPMC10807233
OpenAlexW4387312686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.