Evidence map›Paper›PMID 37788616›Full record

ArticleJournal of addiction medicine

Prescribe to Save Lives: An Intervention to Increase Naloxone Prescribing Among HIV Clinicians.

Peter D Friedmann, Raagini Jawa, Donna Wilson, Susan E Ramsey, Randall Hoskinson, Michelle McKenzie, Alexander Y Walley, Traci C Green, Jeffrey Bratberg, Josiah D Rich

Open access · greenAbstract read
In one paragraph

Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Peter D FriedmannFrom the University of Massachusetts Chan Medical School-Baystate, Springfield, MA (PDF, DW, RH); Center for Research on Healthcare, Section of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA (RJ); The Center for Health and Justice Transformation, The Miriam Hospital, Providence, RI (MM, JDR); The COBRE on Opioids and Overdose at Rhode Island Hospital, Providence, RI (SR, MM, TCG, JDR); The Warren Alpert Medical School of Brown University, Providence, RI (SR, JDR); Grayken Center for Addiction, Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA (AYW); Opioid Policy Research Collaborative, The Heller School for Social Policy and Management, Brandeis University, Waltham, MA (TCG); and the University of Rhode Island College of Pharmacy, Kingston, RI (JB).
Raagini Jawa
Donna Wilson
Susan E Ramsey
Randall Hoskinson
Michelle McKenzie
Alexander Y Walley
Traci C Green
Jeffrey Bratberg
Josiah D Rich
Miriam Hospital · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI JOSIAH D RICH · 2018 to 2026
$23.4M
BU Clinical HIV/AIDS Research Training Program (BU-CHART)T32AI052074 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Benjamin P. Linas · 2003 to 2026
$6.7M
Advancing Clinical Research Training within Addiction Residency ProgramsR25DA033211 · NIDA · BOSTON MEDICAL CENTER · PI Patrick O'Connor, JEFFREY H. SAMET · 2012 to 2026
$4.2M
Implementation to motivate physician response to opioid dependence in HIVsettingR01DA038082 · NIDA · RHODE ISLAND HOSPITAL · PI FRIEDMANN, PETER D, RICH, JOSIAH D · 2014 to 2019
$3.8M
University of Pittsburgh Collaboration in Addiction Training Scholars (PittCATS) ProgramK12DA050607 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jane M. Liebschutz, Erin L Winstanley · 2020 to 2026
$3.2M
NIAID NIH HHS P30 AI042853NIAID NIH HHS T32 AI052074NIDA NIH HHS K12 DA050607NIDA NIH HHS R01 DA038082NIDA NIH HHS R25 DA033211NIGMS NIH HHS P20 GM125507
6 · The paper itself

Abstract

objectivesOverdose is a major cause of preventable death among persons living with HIV. This study aimed to increase HIV clinicians' naloxone prescribing, which can reduce overdose mortality.

methodsWe enrolled 22 Ryan White-funded HIV practices and implemented onsite, peer-to-peer training, posttraining academic detailing, and pharmacy peer-to-peer contact around naloxone prescribing in a nonrandomized stepped wedge design. Human immunodeficiency virus clinicians completed surveys to assess attitudes toward prescribing naloxone at preintervention and 6 and 12 months postintervention. Aggregated electronic health record data measured the number of patients with HIV prescribed and the number of HIV clinicians prescribing naloxone by site over the study period. Models controlled for calendar time and clustering of repeated measures among individuals and sites.

resultsOf 122 clinicians, 119 (98%) completed a baseline survey, 111 (91%) a 6-month survey, and 93 (76%) a 12-month survey. The intervention was associated with increases in self-reported "high likelihood" to prescribe naloxone (odds ratio [OR], 4.1 [1.7-9.4]; P = 0.001). Of 22 sites, 18 (82%) provided usable electronic health record data that demonstrated a postintervention increase in the total number of clinicians who prescribed naloxone (incidence rate ratio, 2.9 [1.1-7.6]; P = 0.03) and no significant effects on sites having at least one clinician who prescribed naloxone (OR, 4.1 [0.7-23.8]; P = 0.11). The overall proportion of all HIV patients prescribed naloxone modestly increased from 0.97% to 1.6% (OR, 2.2 [0.7-6.8]; P = 0.16).

conclusionOn-site, practice-based, peer-to-peer training with posttraining academic detailing was a modestly effective strategy to increase HIV clinicians' prescribing of naloxone.

Indexed as

Drug OverdoseHIV InfectionsAnalgesics, OpioidHumansNaloxoneNarcotic AntagonistsPractice Patterns, Physicians'Analgesics, OpioidNaloxoneNarcotic Antagonists

Identifiers

PMID37788616
PMCPMC10593983
OpenAlexW4379509147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.