ArticleJCI insight2023
Failure to breathe persists without air hunger or alarm following amygdala seizures.
Article in JCI insight, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Autonomic Network Signatures of Interictal Cardiorespiratory Dysfunction in Patients With Temporal Lobe Epilepsy.Neurology · 2026Article
- Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation.Nature communications · 2026Article
- A motor thalamic site in humans that suppresses involuntary breathing without awareness.Journal of neurophysiology · 2026Article
- Cycle-by-cycle respiration waveforms are coupled with the shape of neural oscillations.bioRxiv : the preprint server for biology · 2026Article
- Unraveling SUDEP: Mechanisms of Seizure-Induced Cardiac and Respiratory Impairment.Epilepsy currents · 2026Article
- Narcolepsy-like presentations in intellectual disability with comorbid epilepsy and obstructive sleep apnea: a case-based diagnostic analysis and literature-informed discussion.Frontiers in psychiatry · 2026Article
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions.CNS neuroscience & therapeutics · 2025Review
- Peri-ictal respiratory dysfunction: Expanding the association between mTOR pathway disorders and ictal central apnea.Epilepsia · 2025Article
- Respiratory modulation of heart rate variability after generalized convulsive seizures.Seizure · 2025Article
- Persistent Postictal Central Apnea in Focal Seizures: Incidence, Features, and Imaging Findings.Neurology · 2025Article
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- MK-212 precipitates seizure-induced death in amygdala-kindled mice via a non-5-HTEpilepsy & behavior : E&B · 2025Article
- Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention.Progress in neurobiology · 2025Review
- Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions.Cardiovascular research · 2025Review
- Corticolimbic structures activation during preparation and execution of respiratory manoeuvres in voluntary olfactory sampling: An intracranial EEG study.The Journal of physiology · 2025Article
- The multifunctionality of the brainstem breathing control circuit.Current opinion in neurobiology · 2025Review
- Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.Brain communications · 2025Article
- Central amygdala-to-pre-Bötzinger complex neurotransmission is direct and inhibitory.The European journal of neuroscience · 2024Article
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Authors and funding
21 authors at 6 institutions in 2 countries.
Funding
Abstract
Postictal apnea is thought to be a major cause of sudden unexpected death in epilepsy (SUDEP). However, the mechanisms underlying postictal apnea are unknown. To understand causes of postictal apnea, we used a multimodal approach to study brain mechanisms of breathing control in 20 patients (ranging from pediatric to adult) undergoing intracranial electroencephalography for intractable epilepsy. Our results indicate that amygdala seizures can cause postictal apnea. Moreover, we identified a distinct region within the amygdala where electrical stimulation was sufficient to reproduce prolonged breathing loss persisting well beyond the end of stimulation. The persistent apnea was resistant to rising CO2 levels, and air hunger failed to occur, suggesting impaired CO2 chemosensitivity. Using es-fMRI, a potentially novel approach combining electrical stimulation with functional MRI, we found that amygdala stimulation altered blood oxygen level-dependent (BOLD) activity in the pons/medulla and ventral insula. Together, these findings suggest that seizure activity in a focal subregion of the amygdala is sufficient to suppress breathing and air hunger for prolonged periods of time in the postictal period, likely via brainstem and insula sites involved in chemosensation and interoception. They further provide insights into SUDEP, may help identify those at greatest risk, and may lead to treatments to prevent SUDEP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.