Evidence map›Paper›PMID 37787969›Full record

ArticleHuman cell2024

Activation of cell adhesion and migration is an early event of platelet-rich plasma (PRP)-dependent stimulation of human adipose-derived stem/stromal cells.

Michika Fukui, Fangyuan Lai, Masakatsu Hihara, Toshihito Mitsui, Yuki Matsuoka, Zhongxin Sun, Sakurako Kunieda, Shigeru Taketani, Tokifumi Odaka, Kazu Okuma and 1 more

Abstract read
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Article in Human cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Michika FukuiDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan. mekam0zunevaneva@gmail.com.
Fangyuan LaiDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Masakatsu HiharaDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Toshihito MitsuiDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Yuki MatsuokaDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Zhongxin SunDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Sakurako KuniedaDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Shigeru TaketaniDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Tokifumi OdakaDepartment of Microbiology, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
Kazu OkumaDepartment of Microbiology, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
Natsuko KakudoDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1, Hirakata, Osaka, 573-1010, Japan.
Kansai Medical University · JP

Funding

Japan Society for the Promotion of Science 22K09898
6 · The paper itself

Abstract

Stem cell therapy is a promising treatment in regenerative medicine. Human adipose-derived stem/stromal cells (hASCs), a type of mesenchymal stem cell, are easy to harvest. In plastic and aesthetic surgery, hASC may be applied in the treatment of fat grafting, wound healing, and scar remodeling. Platelet-rich plasma (PRP) contains various growth factors, including platelet-derived growth factor (PDGF), which accelerates wound healing. We previously reported that PRP promotes the proliferation of hASC via multiple signaling pathways, and we evaluated the effect of PRP on the stimulation of hASC adhesion and migration, leading to the proliferation of these cells. When hASCs were treated with PRP, AKT, ERK1/2, paxillin and RhoA were rapidly activated. PRP treatment led to the formation of F-actin stress fibers. Strong signals for integrin β1, paxillin and RhoA at the cell periphery of RPR-treated cells indicated focal adhesion. PRP promoted cell adhesion and movement of hASC, compared with the control group. Imatinib, an inhibitor of the PDGF receptor tyrosine kinase, inhibited the promotion of PRP-dependent cell migration. PDGF treatment of hASCs also stimulated cell adhesion and migration but to a lesser extent than PRP treatment. PRP promoted the adhesion and the migration of hASC, mediated by the activation of AKT in the integrin signaling pathway. PRP treatment was more effective than PDGF treatment in enhancing cell migration. Thus, the ability of PRPs to promote migration of hASC to enhance cell growth is evident.

Indexed as

Mesenchymal Stem CellsPlatelet-Rich PlasmaCell AdhesionCell ProliferationHumansPaxillinProto-Oncogene Proteins c-aktPaxillinProto-Oncogene Proteins c-aktCell migrationHuman adipose-derived stem/stromal cells (hASCs)Platelet-rich plasma (PRP)Signal network

Identifiers

PMID37787969
OpenAlexW4387296290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.