Evidence map›Paper›PMID 37787818›Full record

ArticleBreast cancer research and treatment2024

Relationship between oily fish intake and breast cancer based on estrogen receptor status: a Mendelian randomization study.

Shang Wu, Xindi Ma, Xiangmei Zhang, Chao Shi, Miao Cao, Chao Yang, Yirui Qi, Yunjiang Liu

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Article in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shang Wu *Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Xindi Ma *Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Xiangmei ZhangHebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance, Hebei Medical University, Shijiazhuang, 050017, China.
Chao ShiBreast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Miao CaoHebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance, Hebei Medical University, Shijiazhuang, 050017, China.
Chao YangBreast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Yirui QiHebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance, Hebei Medical University, Shijiazhuang, 050017, China.
Yunjiang LiuBreast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China. lyj818326@outlook.com.ORCID http://orcid.org/0000-0001-7202-2004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe used a Mendelian randomization (MR) method in our research to examine the relationship between genetically determined oily fish intake and breast cancer (BC) incidence.

methodsThe summary data pertaining to the oily fish intake were acquired from the UK Biobank, which consisted of a sample size of 460,443 people. Information on BC was received from the Breast Cancer Association Consortium (BCAC). We analyzed the causal connection between oily fish intake and BC incidence using various methods, including inverse variance weighting (IVW). Heterogeneity was investigated using Cochran's Q test. IVW, MR-Egger, and MR-PRESSO methods were used for sensitivity analysis. In addition, a multivariate MR adjusted for body mass index (BMI) and weight was used for further research.

resultsTwo-sample MR results showed that oily fish intake was negatively associated with total breast cancer (odds ratio (OR) 0.58, 95% confidence interval (CI) 0.39-0.87, IVW method), estrogen receptor-positive (ER +) breast cancer (OR 0.44, 95% CI 0.21-0.93, IVW method), and estrogen receptor-negative (ER-) breast cancer (OR 0.53, 95% CI 0.30-0.93, IVW method). The sensitivity analysis did not observe the presence of heterogeneity and horizontal pleiotropy. In multivariate MR analysis, the negative association between oily fish intake and total breast cancer (P = 0.03) and ER- breast cancer (P = 0.04) risk persisted after adjusting for BMI and body weight. However, no correlation was found in ER + breast cancer (P = 0.30).

conclusionThe oily fish intake has a negatively correlated with the incidence of total breast cancer, particularly in the cases of ER- breast cancer. There is a lack of substantial evidence supporting a link between the oily fish intake and the incidence of ER + breast cancer.

Indexed as

Breast NeoplasmsAnimalsBody Mass IndexFemaleGenome-Wide Association StudyHumansMendelian Randomization AnalysisOdds RatioReceptors, EstrogenReceptors, EstrogenBreast cancerEstrogen receptorGeneticsMendelian randomization studyOily fish intake

Identifiers

PMID37787818

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