Evidence map›Paper›PMID 37787543›Full record

ArticlemBio2023

Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria.

Nuri K Hegelmeyer, Lia A Parkin, Mary L Previti, Joshua Andrade, Raditya Utama, Richard J Sejour, Justin Gardin, Stephanie Muller, Steven Ketchum, Alisa Yurovsky and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Secret code: Encoding promoters by synonymous codons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Nuri K HegelmeyerDepartment of Pharmacological Sciences, Stony Brook University , Stony Brook, New York, USA.ORCID 0000-0003-3606-0155
Lia A ParkinDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.ORCID 0000-0001-7027-2472
Mary L PrevitiDepartment of Pharmacological Sciences, Stony Brook University , Stony Brook, New York, USA.ORCID 0009-0003-0694-1207
Joshua AndradeProteomics Laboratory, New York University Grossman School of Medicine , New York, New York, USA.
Raditya UtamaCold Spring Harbor Laboratory , Cold Spring Harbor, New York, USA.
Richard J SejourDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.
Justin GardinDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.
Stephanie MullerCold Spring Harbor Laboratory , Cold Spring Harbor, New York, USA.
Steven KetchumDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.
Alisa YurovskyDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.
Bruce FutcherDepartment of Microbiology and Immunology, Stony Brook University , Stony Brook, New York, USA.
Sara GoodwinCold Spring Harbor Laboratory , Cold Spring Harbor, New York, USA.
Beatrix UeberheideProteomics Laboratory, New York University Grossman School of Medicine , New York, New York, USA.
Jessica C SeeligerDepartment of Pharmacological Sciences, Stony Brook University , Stony Brook, New York, USA.ORCID 0000-0001-7148-1073
Stony Brook University · USCold Spring Harbor Laboratory · USNew York University · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LEVY, DAVID E · 2003 to 2014
$100.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
Scaling of transcript abundance with cell size and the commitment to cell divisionR01GM127542 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI BRUCE Bruce FUTCHER · 2019 to 2026
$2.6M
Untangling the Inner Workings of the Mycobacterial Cell EnvelopeR35GM128552 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SEELIGER, JESSICA CHUANG · 2018 to 2022
$2.1M
Acquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600k
NCI NIH HHS P30 CA045508NIAID NIH HHS T32 AI007539NIAID NIH HHS U54 AI057158NIGMS NIH HHS R01 GM127542NIGMS NIH HHS R35 GM128552NIGMS NIH HHS T32 GM008444NIGMS NIH HHS T32 GM136572NIH HHS S10 OD010582
6 · The paper itself

Abstract

importance

Indexed as

MycobacteriumSilent MutationCodonRNA, MessengerCodonRNA, Messengercodon pair biasMycobacteriumrecodingtranscriptiontranslationtuberculosis

Identifiers

PMID37787543
PMCPMC10653884
OpenAlexW4387296352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.