Evidence map›Paper›PMID 37787501›Full record

ArticleeLife2023

Novel regulators of islet function identified from genetic variation in mouse islet Ca

Christopher H Emfinger, Lauren E Clark, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Genetics and diet shape the relationship between islet function and whole body metabolism.American journal of physiology. Endocrinology and metabolism · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher H Emfinger *Department of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-9130-4194
Lauren E Clark *Department of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-0209-9716
Brian YandellDepartment of Statistics, University of Wisconsin-Madison, Madison, United States.
Kathryn L SchuelerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.
Shane P SimonettDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-9359-7808
Donnie S StapletonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.
Kelly A MitokDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-0167-3990
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0003-1599-9227
Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-7405-5552
Alan D AttieDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-0568-2261

Funding

Genetic Control of Metabolic Flux in Response to DietRC2DK125961 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2020 to 2024
$8.1M
The Diversity Outbred Diabetes ProjectR01DK101573 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Alan D Attie · 2014 to 2026
$5.3M
Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4M
Metabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta CellsR01DK113103 · NIDDK · YALE UNIVERSITY · PI Matthew J. Merrins · 2017 to 2026
$3.3M
The Role of Sorcs1 and Sortilin in Diabetes SusceptibilityR01DK102948 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2015 to 2019
$1.7M
BLRD VA I01 BX005113NIDDK NIH HHS R01 DK101573NIDDK NIH HHS R01 DK102948NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK127637NIDDK NIH HHS RC2 DK125961NIH HHS R01DK101573NIH HHS R01DK102948NIH HHS R01DK113103NIH HHS R01DK127637NIH HHS RC2DK125961
6 · The paper itself

Abstract

Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca

Indexed as

Islets of LangerhansAmino AcidsAnimalsGenetic VariationGenome-Wide Association StudyGlucoseHumansInsulinMiceAmino AcidsGlucoseInsulincalcium imagingcell biologydiabetesgeneticsgenomicsinsulin secretionisletmousemouse geneticsβ-cell

Identifiers

PMID37787501
PMCPMC10547476

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.