Evidence map›Paper›PMID 37787045›Full record

ArticleJournal of neuroscience research2023

Breast-to-brain metastasis is exacerbated with chemotherapy through blood-cerebrospinal fluid barrier and induces Alzheimer's-like pathology.

B Saatian, K Deshpande, R Herrera, S Sedighi, R Eisenbarth, M Iyer, D Das, A Julian, V Martirosian, A Lowman and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  4. Article
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  9. Molecular Underpinnings of Brain Metastases.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

B SaatianDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
K DeshpandeDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
R HerreraDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
S SedighiDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
R EisenbarthDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
M IyerDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
D DasDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
A JulianDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
V MartirosianDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-6564-3547
A LowmanDepartment of Radiology and Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
P LaVioletteDepartment of Radiology and Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
J RemsikDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
A BoireDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
E SankeyDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
P E FecciDepartment of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
M S ShiroishiBrain Tumor Center, University of Southern California, Los Angeles, California, USA.
F ChowDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
K HurthBrain Tumor Center, University of Southern California, Los Angeles, California, USA.
J NemanDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-6337-9615
University of Southern California · USDuke University · USMedical College of Wisconsin · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
DOCTORAL AND POST-DOCTORAL TRAINING IN CRANIOFACIAL BIOLOGYT90DE021982 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAINE, MICHAEL LANSDELL · 2011 to 2025
$6.2M
Microenvironmental contribution of the Choroid Plexus and Cerebral Spinal Fluid in breast to brain metastasesR01CA223544 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEMAN-EBRAHIM, JOSH · 2019 to 2023
$2.3M
NCI NIH HHS L30 CA242554NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA223544NIDCR NIH HHS T90 DE021982
6 · The paper itself

Abstract

Control of breast-to-brain metastasis remains an urgent unmet clinical need. While chemotherapies are essential in reducing systemic tumor burden, they have been shown to promote non-brain metastatic invasiveness and drug-driven neurocognitive deficits through the formation of neurofibrillary tangles (NFT), independently. Now, in this study, we investigated the effect of chemotherapy on brain metastatic progression and promoting tumor-mediated NFT. Results show chemotherapies increase brain-barrier permeability and facilitate enhanced tumor infiltration, particularly through the blood-cerebrospinal fluid barrier (BCSFB). This is attributed to increased expression of matrix metalloproteinase 9 (MMP9) which, in turn, mediates loss of Claudin-6 within the choroid plexus cells of the BCSFB. Importantly, increased MMP9 activity in the choroid epithelium following chemotherapy results in cleavage and release of Tau from breast cancer cells. This cleaved Tau forms tumor-derived NFT that further destabilize the BCSFB. Our results underline for the first time the importance of the BCSFB as a vulnerable point of entry for brain-seeking tumor cells post-chemotherapy and indicate that tumor cells themselves contribute to Alzheimer's-like tauopathy.

Indexed as

Alzheimer DiseaseBrain NeoplasmsBreast NeoplasmsBrainFemaleHumansMatrix Metalloproteinase 9Matrix Metalloproteinase 9blood-cerebrospinal fluid barrierbrain metastasisbreast cancerchemotherapyCSFtau

Identifiers

PMID37787045
PMCPMC10769085
OpenAlexW4387296326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.