Evidence map›Paper›PMID 37786919›Full record

ArticleChemical communications (Cambridge, England)2023

SWAMNA: a comprehensive platform for analysis of nucleic acid modifications.

Yixuan Xie, Francisca N De Luna Vitorino, Ye Chen, Joanna K Lempiäinen, Chenfeng Zhao, Robert T Steinbock, Zongtao Lin, Xingyu Liu, Emily Zahn, Arabella L Garcia and 2 more

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. 50 years in the making: acpMolecular cell · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yixuan XieDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.ORCID http://orcid.org/0000-0002-8512-6053
Francisca N De Luna VitorinoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Ye ChenDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Joanna K LempiäinenDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Chenfeng ZhaoDepartment of Computer Science & Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
Robert T SteinbockDivision of Protective Immunity and Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zongtao LinDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Xingyu LiuDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Emily ZahnDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Arabella L GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.
Matthew D WeitzmanDivision of Protective Immunity and Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA. bagarcia@wustl.edu.ORCID http://orcid.org/0000-0003-3596-4750

Funding

STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2008 to 2022
$28.3M
Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
Double-stranded RNA during DNA virus infectionR01AI145266 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2019 to 2023
$3.0M
Quantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorderR01HD106051 · NICHD · WASHINGTON UNIVERSITY · PI Benjamin A Garcia · 2022 to 2026
$2.6M
A Mass Spectrometry Approach to the Genetic and Epigenetic Mechanisms Controlling Neuronal IdentityR01NS111997 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAHMANE, NADIA, GARCIA, BENJAMIN A · 2020 to 2024
$2.6M
Defining mechanisms of PKR activation and evasion during Adenovirus infectionF30AI167545 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STEINBOCK, ROBERT THEODORE · 2022 to 2023
$70k
NCI NIH HHS P01 CA196539NIAID NIH HHS F30 AI167545NIAID NIH HHS R01 AI118891NIAID NIH HHS R01 AI145266NIA NIH HHS P01 AG031862NICHD NIH HHS R01 HD106051NINDS NIH HHS R01 NS111997
6 · The paper itself

Abstract

The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications. Herein, we report a general mass spectrometry-based SWATH platform to identify and quantify both RNA and DNA modifications, which we call SWATH analysis of modified nucleic acids (SWAMNA). SWAMNA incorporates the search engine, NuMo finder, enabling the analysis of modifications in native and permethylated form. SWAMNA will aid discoveries that provide new insights into nucleic acid modifications.

Indexed as

Nucleic AcidsMass SpectrometryRNANucleic AcidsRNA

Identifiers

PMID37786919
PMCPMC11006432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.