Evidence map›Paper›PMID 37786726›Full record

ArticlebioRxiv : the preprint server for biology2023

Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons.

Andrew M Bell, Charlotte Utting, Allen C Dickie, Mateusz W Kucharczyk, Raphaëlle Quillet, Maria Gutierrez-Mecinas, Aimi N B Razlan, Andrew H Cooper, Yuxuan Lan, Junichi Hachisuka and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 5 countries.

Andrew M BellSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Charlotte UttingEarlham Institute, Norwich NRU 7UZ, UK.
Allen C DickieSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Mateusz W KucharczykThe Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, UK.
Raphaëlle QuilletSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Maria Gutierrez-MecinasSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Aimi N B RazlanSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Andrew H CooperSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Yuxuan LanEarlham Institute, Norwich NRU 7UZ, UK.
Junichi HachisukaSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Greg A WeirSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Kirsty BannisterThe Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, UK.
Masahiko WatanabeDepartment of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan.
Artur KaniaInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, QC, H2W 1R7, Canada.
Mark A HoonMolecular Genetics Section, National Institute of Dental and Craniofacial Research/NIH, Bethesda, MD, USA.
Iain C MacaulayEarlham Institute, Norwich NRU 7UZ, UK.
Franziska DenkThe Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, UK.
Andrew J ToddSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
University of Glasgow · GBEarlham Institute · GBKing's College London · GBHokkaido University · JPJagiellonian University · PLMontreal Clinical Research Institute · CANational Institute of Dental and Craniofacial Research · US

Funding

Cancer Research UK 26815Medical Research Council MR/T01072X/1Medical Research Council MR/V033638/1Medical Research Council MR/W004739/1MRF_ MRF-160-0015-ELP-DENK-C0844Wellcome Trust
6 · The paper itself

Abstract

The anterolateral system (ALS) is a major ascending pathway from the spinal cord that projects to multiple brain areas and underlies the perception of pain, itch and skin temperature. Despite its importance, our understanding of this system has been hampered by the considerable functional and molecular diversity of its constituent cells. Here we use fluorescence-activated cell sorting to isolate ALS neurons belonging to the Phox2a-lineage for single-nucleus RNA sequencing. We reveal five distinct clusters of ALS neurons (ALS1-5) and document their laminar distribution in the spinal cord using

Indexed as

ALS projection neuronBiological SciencesNeurosciencePainSpinal Dorsal HornThermoeception

Identifiers

PMID37786726
PMCPMC10541585
OpenAlexW4386028205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.