Evidence map›Paper›PMID 37786709›Full record

ArticlebioRxiv : the preprint server for biology2024

Magnetogenetic cell activation using endogenous ferritin.

Lisa Pomeranz, Rosemary Li, Xiaofei Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew Brier, George Vaisey, Putianqi Wang and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Lisa PomeranzLaboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA.
Rosemary LiDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Xiaofei YuSchool of Life Sciences, Fudan University, Shanghai, 200433.ORCID 0000-0002-1712-331X
Leah KellyLaboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA.
Gholamreza HassanzadehVIB Nanobody Core, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels.
Henrik MolinaDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Daniel GrossCurrent address, Dept. of Radiology, Weill Cornell Medicine, 1300 York Avenue New York, NY 10065.
Matthew BrierDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180.
George VaiseyLaboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10065, USA.
Putianqi WangLaboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA.
Maria Jimenez-GonzalezDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adolfo Garcia-OcanaDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jonathan DordickDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180.
Jeffrey FriedmanLaboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA.
Sarah StanleyDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Rockefeller University · USIcahn School of Medicine at Mount Sinai · USRensselaer Polytechnic Institute · USCity of Hope · USCornell University · USFudan University · CNVrije Universiteit Brussel · BE

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Remote Electromagnetic Control of Neural Activity for Treatment of Parkinson's DiseaseR01NS097184 · NINDS · ROCKEFELLER UNIVERSITY · PI DORDICK, JONATHAN S., FRIEDMAN, JEFFREY M · 2016 to 2020
$3.4M
Neural control of pancreatic endocrine function in obesity and diabetesR01DK124461 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STANLEY, SARAH AMY · 2021 to 2024
$2.4M
Remote Modulation of the Peripheral Nervous SystemOT2OD024912 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STANLEY, SARAH AMY · 2017 to 2019
$1.1M
NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK124461NIH HHS OT2 OD024912NINDS NIH HHS R01 NS097184
6 · The paper itself

Abstract

The ability to precisely control the activity of defined cell populations enables studies of their physiological roles and may provide therapeutic applications. While prior studies have shown that magnetic activation of ferritin-tagged ion channels allows cell-specific modulation of cellular activity, the large size of the constructs made the use of adeno-associated virus, AAV, the vector of choice for gene therapy, impractical. In addition, simple means for generating magnetic fields of sufficient strength have been lacking. Toward these ends, we first generated a novel anti-ferritin nanobody that when fused to transient receptor potential cation channel subfamily V member 1, TRPV1, enables direct binding of the channel to endogenous ferritin in mouse and human cells. This smaller construct can be delivered in a single AAV and we validated that it robustly enables magnetically induced cell activation

Identifiers

PMID37786709
PMCPMC10541561
OpenAlexW4381513708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.