Evidence map›Paper›PMID 37786692›Full record

ArticlebioRxiv : the preprint server for biology2023

A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences.

Emily R Hildebrandt, Anushka Sarkar, Rajani Ravishankar, June H Kim, Walter K Schmidt

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emily R HildebrandtDepartment of Biochemistry and Molecular Biology, University of Georgia.
Anushka SarkarDepartment of Biochemistry and Molecular Biology, University of Georgia.
Rajani RavishankarDepartment of Biochemistry and Molecular Biology, University of Georgia.
June H KimDepartment of Biochemistry and Molecular Biology, University of Georgia.
Walter K SchmidtDepartment of Biochemistry and Molecular Biology, University of Georgia.
University of Georgia · US

Funding

Determining the scope of prenylatable protein sequencesR01GM132606 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, SCHMIDT, WALTER K · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM132606
6 · The paper itself

Abstract

The C-terminal CaaX sequence (cysteine-aliphatic-aliphatic-any of several amino acids) is subject to isoprenylation on the conserved cysteine and is estimated to occur in 1-2% of proteins within yeast and human proteomes. Recently, non-canonical CaaX sequences in addition to shorter and longer length CaX and CaaaX sequences have been identified that can be prenylated. Much of the characterization of prenyltransferases has relied on the yeast system because of its genetic tractability and availability of reporter proteins, such as the

Indexed as

CaaXfarnesylationgeranylgeranylation

Identifiers

PMID37786692
PMCPMC10541624
OpenAlexW4386933883

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.