Evidence map›Paper›PMID 37786686›Full record

ArticlebioRxiv : the preprint server for biology2023

NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma.

Iuliia Topchu, Igor Bychkov, Demirkan Gursel, Petr Makhov, Yanis Boumber

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Iuliia TopchuRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL, 60611.
Igor BychkovRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL, 60611.
Demirkan GurselPathology Core Facility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, Chicago, IL, 60611.
Petr MakhovCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, 19111.
Yanis BoumberRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL, 60611.
Northwestern University · USFox Chase Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Targeting Musashi-2 (MSI2) regulation of VEGFR2 / VEGF-A in lung cancerR01CA218802 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI BOUMBER, YANIS · 2018 to 2022
$1.9M
Tumor-specific anti-angiogenic anti-CD70-FGF/VEGF-trap fusion antibodies for renal cancer therapyR21CA263362 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI MAKHOV, PETR B. · 2022 to 2023
$478k
NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA218802NCI NIH HHS R21 CA263362
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Despite advances in therapeutic management and immunotherapy, the five-year survival rate for head and neck cancer remains at ~66% of all diagnosed cases. A better definition of drivers of HPV-negative HNSCC that are targetable points of tumor vulnerability could lead to significant clinical advances. NSD1 is a histone methyltransferase which catalyzes histone H3 lysine 36 di-methylation (H3K36me

Indexed as

Akt/mTORC1autophagyHead and neck cancer squamous cell carcinoma (HNSCC)NSD1

Identifiers

PMID37786686
PMCPMC10541623
OpenAlexW4386946932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.