Evidence map›Paper›PMID 37786671›Full record

ArticlebioRxiv : the preprint server for biology2023

Integrative

Christian G Cerda-Smith, Haley M Hutchinson, Annie Liu, Viraat Y Goel, Corriene Sept, Holly Kim, Salvador Casaní-Galdón, Katherine G Burkman, Christopher F Bassil, Anders S Hansen and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Christian G Cerda-SmithDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine; Durham, NC 27710, USA.
Haley M HutchinsonDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine; Durham, NC 27710, USA.
Annie LiuDepartment of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.
Viraat Y GoelDepartment of Biological Engineering, Massachusetts Institute of Technology; Cambridge, 02139, USA.
Corriene SeptBroad Institute; Cambridge, MA 02139, USA.
Holly KimDepartment of Radiation Oncology, Duke University School of Medicine; Durham, NC 27710, USA.
Salvador Casaní-GaldónBroad Institute; Cambridge, MA 02139, USA.
Katherine G BurkmanDepartment of Radiation Oncology, Duke University School of Medicine; Durham, NC 27710, USA.
Christopher F BassilDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine; Durham, NC 27710, USA.
Anders S HansenDepartment of Biological Engineering, Massachusetts Institute of Technology; Cambridge, 02139, USA.
Martin J AryeeBroad Institute; Cambridge, MA 02139, USA.
Sarah E JohnstoneBroad Institute; Cambridge, MA 02139, USA.
Christine E EylerDepartment of Radiation Oncology, Duke University School of Medicine; Durham, NC 27710, USA.
Kris C WoodDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine; Durham, NC 27710, USA.
Duke University · USBroad Institute · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Interdisciplinary training: Statistical Genetics/Genomics and Computational BiologyT32GM135117 · NIGMS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Curtis Huttenhower, XIHONG LIN · 2020 to 2026
$3.1M
DYNAMIC BOTTOM-UP DISSECTION OF CHROMATIN LOOPING AND GENE REGULATIONDP2GM140938 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2020 to 2020
$2.3M
Selectively targeting apoptosis in PIK3CA mutant colorectal cancersR01CA207083 · NCI · DUKE UNIVERSITY · PI WOOD, KRIS C. · 2016 to 2020
$1.8M
Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platformK08CA263300 · NCI · DUKE UNIVERSITY · PI Christine Elissa Eyler · 2022 to 2026
$1.2M
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancerR33CA257878 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2021 to 2023
$1.1M
Elucidating the impact of DNA hypomethylation on genome organization and anti-tumor transcriptional programs.K08CA259623 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSTONE, SARAH E · 2021 to 2025
$976k
Evaluation of voltage-gated calcium ion channels as a therapeutic target in intrahepatic cholangiocarcinomaF32CA268527 · NCI · DUKE UNIVERSITY · PI LIU, ANNIE · 2022 to 2023
$156k
Identification and Characterization of Novel Cis-Regulatory Elements Controlling PTEN ExpressionF30CA247323 · NCI · DUKE UNIVERSITY · PI CERDA-SMITH, CHRISTIAN GONZALO · 2020 to 2022
$129k
NCI NIH HHS F30 CA247323NCI NIH HHS F32 CA268527NCI NIH HHS K08 CA259623NCI NIH HHS K08 CA263300NCI NIH HHS R01 CA207083NCI NIH HHS R33 CA257878NIGMS NIH HHS DP2 GM140938NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM135117
6 · The paper itself

Abstract

Enhancers possess both structural elements mediating promoter looping and functional elements mediating gene expression. Traditional models of enhancer-mediated gene regulation imply genomic overlap or immediate adjacency of these elements. We test this model by combining densely-tiled CRISPRa screening with nucleosome-resolution Region Capture Micro-C topology analysis. Using this integrated approach, we comprehensively define the

Identifiers

PMID37786671
PMCPMC10541578
OpenAlexW4386967421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.