Evidence map›Paper›PMID 37786251›Full record

ArticleGut microbes2023

Diet and gut microbial associations in irritable bowel syndrome according to disease subtype.

Yiqing Wang, Wenjie Ma, Raaj Mehta, Long H Nguyen, Mingyang Song, David A Drew, Francesco Asnicar, Curtis Huttenhower, Nicola Segata, Jonathan Wolf and 4 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Frontiers in pharmacology · 2026
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  15. Comprehensive antibiotic resistome comparison ofCurrent research in microbial sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Yiqing WangClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Wenjie MaClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Raaj MehtaClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Long H NguyenClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Mingyang SongClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
David A DrewClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Francesco AsnicarDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Curtis HuttenhowerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nicola SegataDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Jonathan WolfZoe Ltd, London, UK.
Tim SpectorDepartment of Twin Research, King's College London, London, UK.
Sarah BerryDepartment of Nutritional Sciences, King's College London, London, UK.
Kyle StallerClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Andrew T ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USKing's College London · GBMassachusetts General Hospital · USBrigham and Women's Hospital · USEuropean Institute of Oncology · ITUniversity of Trento · ITZOE (United Kingdom) · GB

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1991 to 2026
$35.3M
Precision Prevention Research ProgramR35CA253185 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew T Chan · 2020 to 2026
$6.9M
The Role of Fiber in the Etiopathogenesis of Fecal IncontinenceK23DK120945 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STALLER, KYLE · 2020 to 2024
$1.0M
Dietary strategies for rational manipulation of the gut microbiome in inflammatory bowel diseaseK23DK125838 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, LONG H · 2020 to 2024
$1.0M
Exploiting public metagenomic data to uncover cancer-microbiome relationshipsU01CA230551 · NCI · GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY · PI WALDRON, LEVI · 2019 to 2019
$464k
Biotechnology and Biological Sciences Research CouncilMedical Research CouncilNCI NIH HHS R35 CA253185NCI NIH HHS U01 CA230551NIDDK NIH HHS K23 DK120945NIDDK NIH HHS K23 DK125838NIDDK NIH HHS P30 DK043351Wellcome Trust
6 · The paper itself

Abstract

The role of diet and the gut microbiome in the etiopathogenesis of irritable bowel syndrome (IBS) is not fully understood. Therefore, we investigated the interplay between dietary risk factors and gut microbiota in IBS subtypes using a food frequency questionnaire and stool metagenome data from 969 participants aged 18-65 years in the ZOE PREDICT 1 study, an intervention study designed to predict postprandial metabolic responses. We identified individuals with IBS subtype according to the Rome III criteria based on predominant bowel habits during symptom onset: diarrhea (i.e. looser), constipation (i.e. harder), and mixed. Participants with IBS-D (

Indexed as

Gastrointestinal MicrobiomeIrritable Bowel SyndromeConstipationDiarrheaDietHumansdiarrheaFiberfunctional bowel disorderglycan metabolismmicrobial enzymes

Identifiers

PMID37786251
PMCPMC10549191
OpenAlexW4387296046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.