SynthesisItalian journal of pediatrics2023
Predictors of extubation failure in newborns: a systematic review and meta-analysis.
Synthesis in Italian journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Invasive Ventilation Strategies in Neonates.Indian pediatrics · 2025Review
- Use of Prophylactic Methylxanthines to Prevent Extubation Failure in Preterm Neonates with a Birth Weight of 1250-2499 g: A Propensity Score-Matched Analysis.Journal of clinical medicine · 2025Article
- A nomogram to predict extubation failure in infants born before 32 gestational weeks: a single-center retrospective study.Translational pediatrics · 2025Article
- Predicting extubation failure in neonates: The role of lung ultrasound and corrected gestational age in safe weaning in the NICU.European journal of pediatrics · 2025Observational
- Prognostic factors for successful extubation in newborns with congenital diaphragmatic hernia.Frontiers in pediatrics · 2025Article
- Risk factors and adverse outcomes of extubation failure in preterm infants ≤32 weeks with neonatal respiratory distress syndrome.Frontiers in pediatrics · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Extubation failure (EF) is a significant concern in mechanically ventilated newborns, and predicting its occurrence is an ongoing area of research. To investigate the predictors of EF in newborns undergoing planned extubation, we conducted a systematic review and meta-analysis. A systematic literature search was conducted in PubMed, Web of Science, Embase, and Cochrane Library for studies published in English from the inception of each database to March 2023. The PRISMA guidelines were followed in all phases of this systematic review. The Risk of Bias Assessment for Nonrandomized Studies tool was used to assess methodological quality. Thirty-four studies were included, 10 of which were overall low risk of bias, 15 of moderate risk of bias, and 9 of high risk of bias. The studies reported 43 possible predictors in six broad categories (intrinsic factors; maternal factors; diseases and adverse conditions of the newborn; treatment of the newborn; characteristics before and after extubation; and clinical scores and composite indicators). Through a qualitative synthesis of 43 predictors and a quantitative meta-analysis of 19 factors, we identified five definite factors, eight possible factors, and 22 unclear factors related to EF. Definite factors included gestational age, sepsis, pre-extubation pH, pre-extubation FiO
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