Evidence map›Paper›PMID 37784183›Full record

ReviewBiomarker research2023

Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway.

Jing Zhang, Qizhi Luo, Xin Li, Junshuang Guo, Quan Zhu, Xiaofang Lu, Leiyan Wei, Zhiqing Xiang, Manqing Peng, Chunlin Ou and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomarker research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jing ZhangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Qizhi LuoDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Xin LiDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Junshuang GuoDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Quan ZhuDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Xiaofang LuDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Leiyan WeiDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Zhiqing XiangDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Manqing PengDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China.
Chunlin OuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. ouchunlin@csu.edu.cn.
Yizhou ZouDepartment of Immunology, School of Basic Medicine, Central South University, Changsha, 410000, Hunan, China. yizhou_zou@sina.com.
Central South University · CNXiangya Hospital Central South University · CN

Funding

Central South University Innovation-Driven Research Programme 2023CXQD075National Natural Science Foundation of China 82171763National Natural Science Foundation of China 82373062Outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China 2022JJ2009
6 · The paper itself

Abstract

Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D receptor (NKG2D) that is expressed in various tumour cells. Given that the MICA/NKG2D signalling system is critically embedded in the innate and adaptive immune responses, it is particularly involved in the surveillance of cancer and viral infections. Emerging evidence has revealed the important roles of non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in different cancer types. We searched for all relevant publications in the PubMed, Scopus and Web of Science database using the keywords ncRNA, MICA, NKG2D, cancer, and miRNAs. All relevant studies published from 2008 to the 2023 were retrieved and collated. Notably, we found that miRNAs can target to NKG2D mRNA and MICA mRNA 3'-untranslated regions (3'-UTR), leading to translation inhibition of NKG2D and MICA degradation. Several immune-related MICA/NKG2D pathways may be dysregulated in cancer with aberrant miRNA expressions. At the same time, the competitive endogenous RNA (ceRNA) hypothesis holds that circRNAs, lncRNAs, and mRNAs induce an abnormal MICA expression by directly targeting downstream miRNAs to mediate mRNA suppression in cancer. This review summarizes the novel mechanism of immune escape in the ncRNA-related MICA/NKG2D pathway mediated by NK cells and cancer cells. Moreover, we identified the miRNA-NKG2D, miRNA-MICA and circRNA/lncRNA/mRNA-miRNA-mRNA/MICA axis. Thus, we were particularly concerned with the regulation of mediated immune escape in the MICA/NKG2D pathway by ncRNAs as potential therapeutic targets and diagnostic biomarkers of immunity and cancer.

Indexed as

CancersceRNAcircRNAImmunitylncRNAMICAmicroRNANKG2D

Identifiers

PMID37784183
PMCPMC10546648
OpenAlexW4387253858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.