Evidence map›Paper›PMID 37784127›Full record

ArticleThrombosis journal2023

Hyperlipidemia in immune thrombocytopenia: a retrospective study.

Shouqing Han, Hui Lu, Yafei Yu, Xinguang Liu, Fangmiao Jing, Liang Wang, Yajing Zhao, Ming Hou

Open access · goldAbstract read
In one paragraph

Article in Thrombosis journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shouqing HanDepartment of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong, China.
Hui LuAffiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Yafei YuDepartment of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong, China.
Xinguang LiuDepartment of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong, China.
Fangmiao JingDepartment of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.
Liang WangAffiliated Hospital of Weifang Medical University, Weifang, Shandong, China. 18654620224@163.com.
Yajing ZhaoDepartment of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong, China. zhaoyajing93115@163.com.
Ming HouDepartment of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong, China. houming@medmail.com.cn.
Qilu Hospital of Shandong University · CNWeifang Medical University · CN

Funding

National Natural Science Foundation of China 81973994National Natural Science Foundation of China 82000123National Natural Science Foundation of China 82000124National Natural Science Foundation of China 82170123Natural Science Foundation of Shandong Province ZR2020QH091
6 · The paper itself

Abstract

backgroundImmune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown.

methodsWe retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses.

resultsWe found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients.

conclusionsOur present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development.

Indexed as

BleedingImmune thrombocytopeniaLipid metabolismStatins

Identifiers

PMID37784127
PMCPMC10544441
OpenAlexW4387264980

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.