Evidence map›Paper›PMID 37784057›Full record

ArticleBMC veterinary research2023

Low proviral load in the Kumamoto strain of Japanese Brown cattle infected with the bovine leukemia virus.

Toshiaki Inenaga, Koh Fukuoka, Mikiya Sumida, Sakiko Aiba, Kohei Nishikaku, Yuta Matsuno, Tomoko Kobayashi, Kazuhiko Imakawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Toshiaki InenagaLaboratory of Animal Management Science, Department of Animal Science, School of Agriculture, Tokai University, Sugido 871-12, Mashiki, Kumamoto, 861-2205, Japan. inenaga-t@tsc.u-tokai.ac.jp.
Koh FukuokaKumamoto Prefectural Central Kumamoto Livestock Sanitation Center, Shizume 1666-1, Jonan-machi, Minami-kuKumamoto, 861-4215, Japan.
Mikiya SumidaLaboratory of Animal Management Science, Department of Animal Science, School of Agriculture, Tokai University, Sugido 871-12, Mashiki, Kumamoto, 861-2205, Japan.
Sakiko AibaLaboratory of Animal Management Science, Department of Animal Science, School of Agriculture, Tokai University, Sugido 871-12, Mashiki, Kumamoto, 861-2205, Japan.
Kohei NishikakuLaboratory of Animal Health, Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, Funako 1737, Atsugi, Kanagawa, 243-0034, Japan.
Yuta MatsunoResearch Institute of Agriculture, Tokai University, Toroku 9-1-1, Higashi-ku, Kumamoto, 862-8652, Japan.
Tomoko KobayashiLaboratory of Animal Health, Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, Funako 1737, Atsugi, Kanagawa, 243-0034, Japan.
Kazuhiko ImakawaResearch Institute of Agriculture, Tokai University, Toroku 9-1-1, Higashi-ku, Kumamoto, 862-8652, Japan.
Kyushu Tokai University · JPTokyo University of Agriculture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Kumamoto strain of Japanese Brown (JBRK) cattle is a sub-breed of Wagyu and has a different genetic background than that of Japanese Black (JB) cattle. Bovine leukemia virus (BLV) is the pathogen causing enzootic bovine leukosis (EBL), the predominant type of bovine leukosis (BL). EBL is one of the most common bovine infectious diseases in dairy countries, including Japan. Some host genetic factors, including the bovine leukocyte antigen (BoLA)-DRB3 gene, have been associated with the proviral load (PVL) of BLV and/or onset of EBL. Here, we determined the number of BL cases by analyzing prefectural case records in detail. We measured the PVL of BLV-infected JBRK cattle and compared it with that obtained for other major breeds, JB and Holstein-Friesian (HF) cattle. Finally, the relationship between PVL levels and BoLA-DRB3 haplotypes was investigated in BLV-infected JBRK cattle.

resultsWe determined the number of BL cases recorded over the past ten years in Kumamoto Prefecture by cattle breed. A limited number of BL cases was observed in JBRK cattle. The proportion of BL cases in the JBRK was lower than that in JB and HF. The PVL was significantly lower in BLV-infected JBRK cattle than that in the JB and HF breeds. Finally, in BLV-infected JBRK cattle, the PVL was not significantly affected by BoLA-DRB3 alleles and haplotypes. BoLA-DRB3 allelic frequency did not differ between BLV-infected JBRK cattle with low PVL and high PVL.

conclusionsTo our knowledge, this is the first report showing that BL occurred less in the JBRK population of Kumamoto Prefecture. After BLV-infection, the PVL was significantly lower in JBRK cattle than that in JB and HF breeds. The genetic factors implicated in maintaining a low PVL have yet to be elucidated, but the BoLA-DRB3 haplotypes are likely not involved.

Indexed as

Cattle DiseasesEnzootic Bovine LeukosisLeukemia Virus, BovineAnimalsCattleGene FrequencyHistocompatibility Antigens Class IIProvirusesHistocompatibility Antigens Class IIBoLA-DRB3Bovine leukemia virusCattleEnzootic bovine leukosisHolstein-FriesianJapanese blackJapanese BrownProviral load

Identifiers

PMID37784057
PMCPMC10544446
OpenAlexW4387264893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.