ArticleNature cancer2023
Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia.
Article in Nature cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Atlantic to Pacific: Outbreak of bivalve transmissible neoplasia detected in hybridizing soft-shell clams and eDNA in Puget Sound.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Beyond Mice and Men: Alternative Vertebrate and Invertebrate Models in Cancer Biology.Annual review of cancer biology · 2026Article
- External immune sentinels in the seawater ecosystem: the specialization of bivalve hemocytes.Frontiers in immunology · 2026Article
- Comparative Genomics of Sex-Determination-Related Genes Reveals Shared Evolutionary Patterns Between Bivalves and Mammals, but Not Fruit Flies.Molecular ecology · 2025Article
- Variation in natural infection outcomes and cancer cell release from soft-shell clams (Mya arenaria) with bivalve transmissible neoplasia.PLoS pathogens · 2025Article
- Simple Transgene Overexpression using Scallop Hemocyte Culture Platform Enables Functional Genetic Research in Molluscs.Marine biotechnology (New York, N.Y.) · 2025Article
- Horizontal transfer of nuclear DNA in transmissible cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- No Evidence for Distinct Transcriptomic Subgroups of Devil Facial Tumor Disease (DFTD).Evolutionary applications · 2025Article
- Gene expression in soft-shell clam (Mya arenaria) transmissible cancer reveals survival mechanisms during host infection and seawater transfer.PLoS genetics · 2025Article
- Identification of an Outbreak of Bivalve Transmissible Neoplasia in Soft-Shell Clams (bioRxiv : the preprint server for biology · 2024Article
- Evolution of transmissible cancers: An adaptive, plastic strategy of selfish genetic elements?iScience · 2024Review
- Unravelling epigenetic mechanisms in Cerastoderma edule genome: a comparison of healthy and neoplastic cockles.Molecular genetics and genomics : MGG · 2024Article
- TheViruses · 2024Article
- A deep dive into transmissible cancer evolution in bivalve mollusks.Nature cancer · 2023Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living past the death of the founder animal in which the cancer initiated. We investigated the evolutionary history of a cancer lineage that has spread though the soft-shell clam (Mya arenaria) population by assembling a chromosome-scale soft-shell clam reference genome and characterizing somatic mutations in transmissible cancer. We observe high mutation density, widespread copy-number gain, structural rearrangement, loss of heterozygosity, variable telomere lengths, mitochondrial genome expansion and transposable element activity, all indicative of an unstable cancer genome. We also discover a previously unreported mutational signature associated with overexpression of an error-prone polymerase and use this to estimate the lineage to be >200 years old. Our study reveals the ability for an invertebrate cancer lineage to survive for centuries while its genome continues to structurally mutate, likely contributing to the evolution of this lineage as a parasitic cancer.
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