ArticleNature communications2023
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
Registry-linked trialAbstract read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Genetic risk stratification of common diseases in breast cancer survivors: a population-based cohort study.JNCI cancer spectrum · 2026Article
- Polygenic risk scores, adiposity, and disease transition in type 2 diabetes and colorectal cancer comorbidity: a population-based Chinese cohort study.BMC cancer · 2026Observational
- Emerging trends in the global burden of colorectal cancer.Nature reviews. Clinical oncology · 2026Review
- Interaction of genetic and lifestyle risk scores on colorectal cancer risk across 5 racial and ethnic populations.Journal of the National Cancer Institute · 2026Article
- Integrating Polygenic Risk and Ocular Phenotyping Reveals an Axial-Length-Dominant Mechanism in High and Extreme High Myopia.Ophthalmology science · 2026Article
- Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications.The Prostate · 2026Article
- Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.JNCI cancer spectrum · 2026Article
- MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle.medRxiv : the preprint server for health sciences · 2026Article
- Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing.Cancers · 2025Article
- European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.British journal of haematology · 2025Article
- Multiple polygenic score approach in colorectal cancer risk prediction.Scientific reports · 2025Article
- An Integrative Polygenic and Epigenetic Risk Score for Overweight-related Hypertension in Chinese Population.Genomics, proteomics & bioinformatics · 2025Article
- The Translational Research Program in Cancer Differences across Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.Human genomics · 2025Article
- Polygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk.JCO precision oncology · 2025Article
- Estimating Cancer Penetrance in Carriers of BRCA2 Pathogenic Variants Using Cancer-Specific Polygenic Scores.Cancer medicine · 2025Observational
- Building research infrastructure to advance precision medicine in colorectal cancer.JNCI cancer spectrum · 2025Article
- Unraveling Early Onset Disparities and Determinants: An Analysis of Colorectal Cancer Outcomes and Trends in Texas.Cureus · 2025Article
- Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers.International journal of cancer · 2025Article
Corrections and comments
- Update of
Authors and funding
129 authors.
Minta ThomasPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-9337-7015
Yu-Ru SuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Elisabeth A RosenthalDepartment of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0001-6042-4487
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0002-0900-5735
Stephanie L SchmitGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-5931-1194
Maria N TimofeevaDanish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-2503-4253
Zhishan ChenDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Ceres Fernandez-RozadillaInstituto de Investigacion Sanitaria de Santiago (IDIS), Choupana sn, 15706, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0001-7330-4804
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Reseach, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0001-9663-4611
Neil MurphyNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID http://orcid.org/0000-0003-3347-8249
Robert Carreras-TorresDigestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, 17190, Girona, Spain.ORCID http://orcid.org/0000-0002-2925-734X
Virginia Diez-ObreroUnit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, 08908, Spain.
Franzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Shangqing JiangPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Aesun ShinDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, South Korea.ORCID http://orcid.org/0000-0002-6426-1969
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Amanda I PhippsPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
Andrea Gsur.Center for Cancer Research, Medical University Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-9795-1528
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7284-6767
Ann G ZauberDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1764-5994
Anna H WuUniversity of Southern California, Preventative Medicine, Los Angeles, CA, USA.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Caroline Y UmDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-5449-6230
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chris GignouxColorado Center for Personalized Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-9728-6567
Christina NewtonDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Christopher A HaimanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
D Timothy BishopLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-8752-8785
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3000, Australia.ORCID http://orcid.org/0000-0003-2225-6675
David R CrosslinDepartment of Bioinformatics and Medical Education, University of Washington Medical Center, Seattle, WA, 98195, USA.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Dong-Hyun KimDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea.
Elizabeth HauserVA Cooperative Studies Program Epidemiology Center, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Erin SiegelCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-1779-2510
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3073-7463
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-4946-9099
Heather HampelDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-7558-9794
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6129-1572
Isao Oze.Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0002-0762-1147
Jae Hwan Oh.Research Institute and Hospital, National Cancer Center, Goyang, South Korea, South Korea.
Jeffrey K Lee.Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, San Francisco, CA, USA.
Jennifer L SchneiderDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8919-1971
Jeongseon KimDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea.ORCID http://orcid.org/0000-0002-0889-2686
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-6027-9806
Jiayin ZhengPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0002-5559-6847
Jochen HampeDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.ORCID http://orcid.org/0000-0002-2421-6127
Joel GreensonDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48104, USA.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Julie R PalmerSlone Epidemiology Center, School of Medicine, Boston University, Boston, MA, USA.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-0582-8005
Keitaro MatsuoDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Keum Ji JungInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.ORCID http://orcid.org/0000-0003-4993-0666
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Ludmila VodickovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Luis BujandaDepartment of Gastroenterology, Biodonostia Health Research Institute, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.ORCID http://orcid.org/0000-0002-4353-9968
Marc J GunterNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Marco MatejcicMoffitt Cancer Center, Tampa, FL, USA.
Mark A JenkinsUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3000, Australia.ORCID http://orcid.org/0000-0002-8964-6160
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Mauro D'AmatoDepartment of Medicine and Surgery, LUM University, Camassima, Italy.
Meilin WangDepartment of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-4996-958X
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8307-3197
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, Canada.
Michelle KimPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Mingyang SongDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1324-0316
Motoki IwasakiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Mulong DuDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-2733-6490
Natalia UdaltsovaDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Norie SawadaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9936-1476
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Peter T CampbellDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-8786-0043
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-9384-5648
Rachel PearlmanDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7153-2766
Robert S SteinfelderPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Robert W HaileSamuel Oschin Comprehensive Cancer Institute, CEDARS-SINAI, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6902-1836
Rosita VandenputtelaarDepartment of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ross L PrenticePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Sébastien KüryNantes Université, CHU Nantes, Service de Génétique Médicale, F-44000, Nantes, France.ORCID http://orcid.org/0000-0001-5497-0465
Sergi Castellví-BelGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1217-5097
Shoichiro TsuganeDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4105-2774
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Soo Chin LeeNational University Cancer Institute, Singapore, Singapore.
Stefanie Brezina.Center for Cancer Research, Medical University Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5238-6900
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3834-1535
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
Susan VadaparampilDepartments of Epidemiology and Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0002-4173-7530
Taiki YamajiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Veronika VymetalkovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9320-8684
Wei-Hua JiaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-0528-8715
Xiao-Ou ShuVanderbilt University Medical Center, Nashville, TN, USA.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Yoon-Ok AhnDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, South Korea.
Zsofia K StadlerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6985-2864
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-9692-101X
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-7641-059X
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3676-8954
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-5439-1500
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Reinier MeesterDepartment of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.
Victor MorenoOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2818-5487
Jane C FigueiredoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Iris Lansdorp VogelaarDepartment of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.
Malcolm G DunlopColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, U, Germany.ORCID http://orcid.org/0000-0002-3033-5851
Stephen B GruberDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-8656-7822
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0918-661X
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Reseach, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-5268-0242
Gail P JarvikDepartment of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, 98195, USA.
Ian P TomlinsonEdinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0003-3037-1470
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Douglas A CorleyDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA. upeters@fredhutch.org.ORCID http://orcid.org/0000-0001-5666-9318
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA. lih@fredhutch.org.ORCID http://orcid.org/0000-0001-8168-4712
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MVariation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MGenome-Wide Association Study of Nonsynonymous SNPs in Colon CancerR01CA059045 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 1994 to 2011
$11.5MUsing Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GAUDERMAN, WILLIAM JAMES, LE MARCHAND, LOIC · 2016 to 2020
$9.6MLeveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2MAn integrative omics approach to investigate gene-environment interaction in colorectal cancer riskR01CA273198 · NCI · FRED HUTCHINSON CANCER CENTER · PI William JAMES GAUDERMAN, ULRIKE PETERS · 2023 to 2026
$3.5MAdvancing equity in colorectal cancer genetic risk prediction through expansion of racial/ethnic minority representationR01CA244588 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2020 to 2024
$3.5MIntegration of epidemiology, pathology, immunology and outcomes in colorectal cancerR01CA263318 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI STEPHEN B GRUBER · 2022 to 2026
$3.4MComprehensive Colorectal Cancer Risk Prediction to Inform Personalized ScreeningR01CA206279 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CORLEY, DOUGLAS ALLEN, HAYES, RICHARD BERNARD · 2017 to 2020
$2.7MCancer Research UK 18927Cancer Research UK 25514Medical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MC_UU_00007/1NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA206279NCI NIH HHS R01 CA244588NCI NIH HHS R01 CA263318NCI NIH HHS R01 CA273198NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA185094NCI NIH HHS U01 CA206110NCI NIH HHS U01 CA261339NHGRI NIH HHS U01 HG008657World Health Organization 001
Abstract
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
Indexed as
Colorectal NeoplasmsEthnicityGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMultifactorial InheritancePolymorphism, Single NucleotideRisk Factors
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NCT02328677ClinicalTrials.gov
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