Evidence map›Paper›PMID 37783687›Full record

ArticleTranslational psychiatry2023

adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment.

Barbara D Fontana, Florian Reichmann, Ceinwen A Tilley, Perrine Lavlou, Alena Shkumatava, Nancy Alnassar, Courtney Hillman, Karl Ægir Karlsson, William H J Norton, Matthew O Parker

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Barbara D FontanaSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Florian ReichmannDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0002-5833-3698
Ceinwen A TilleyDepartment of Genetics and Genome Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, LE1 7RH, UK.
Perrine LavlouInstitut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.
Alena ShkumatavaInstitut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.
Nancy AlnassarSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Courtney HillmanSurrey Sleep Research Centre, University of Surrey, Guildford, UK.
Karl Ægir KarlssonSchool of Science and Engineering, Reykjavik University, Reykjavik, Iceland.
William H J NortonDepartment of Genetics and Genome Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, LE1 7RH, UK. will.norton@leicester.ac.uk.ORCID http://orcid.org/0000-0002-3244-0145
Matthew O ParkerSurrey Sleep Research Centre, University of Surrey, Guildford, UK. matthew.parker@surrey.ac.uk.ORCID http://orcid.org/0000-0002-7172-5231
Centre National de la Recherche Scientifique · FRUniversity of Portsmouth · GBUniversity of Surrey · GBEötvös Loránd University · HUMedical University of Graz · ATReykjavík University · ISUniversity of Leicester · GB

Funding

Austrian Science Fund FWF J 4090Austrian Science Fund FWF P 35774
6 · The paper itself

Abstract

Externalizing disorders (ED) are a cause of concern for public health, and their high heritability makes genetic risk factors a priority for research. Adhesion G-Protein-Coupled Receptor L3 (ADGRL3) is strongly linked to several EDs, and loss-of-function models have shown the impacts of this gene on several core ED-related behaviors. For example, adgrl3.1

Indexed as

Attention Deficit Disorder with HyperactivityZebrafishAnimalsBrainNorepinephrineReceptors, G-Protein-CoupledNorepinephrineReceptors, G-Protein-Coupled

Identifiers

PMID37783687
PMCPMC10545713
OpenAlexW4387259679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.