Evidence map›Paper›PMID 37783684›Full record

ArticleScientific reports2023

A deep learning model to triage and predict adenocarcinoma on pancreas cytology whole slide imaging.

Andrew Sohn, Daniel Miller, Efrain Ribeiro, Nakul Shankar, Syed Ali, Ralph Hruban, Alexander Baras

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Andrew SohnDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel MillerDepartment of Pathology, Saint Louis University School of Medicine, St. Louis, USA.
Efrain RibeiroDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nakul ShankarDepartment of Pathology, University of Colorado, Boulder, USA.
Syed AliDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ralph HrubanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexander BarasDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. baras@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USSaint Louis University · USUniversity of Colorado Boulder · US

Funding

Opportunities for Pathology Trainees in Cancer ResearchT32CA193145 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A., EBERHART, CHARLES G · 2015 to 2025
$2.6M
NCI NIH HHS T32 CA193145
6 · The paper itself

Abstract

Pancreatic fine-needle aspirations are the gold-standard diagnostic procedure for the evaluation of pancreatic ductal adenocarcinoma. A suspicion for malignancy can escalate towards chemotherapy followed by a major surgery and therefore is a high-stakes task for the pathologist. In this paper, we propose a deep learning framework, MIPCL, that can serve as a helpful screening tool, predicting the presence or absence of cancer. We also reproduce two deep learning models that have found success in surgical pathology for our cytopathology study. Our MIPCL significantly improves over both models across all evaluated metrics (F1-Score: 87.97% vs 88.70% vs 91.07%; AUROC: 0.9159 vs. 0.9051 vs 0.9435). Additionally, our model is able to recover the most contributing regions on the slide for the final prediction. We also present a dataset curation strategy that increases the number of training examples from an existing dataset, thereby reducing the resource burden tied to collecting and scanning additional cases.

Indexed as

AdenocarcinomaDeep LearningPancreatic NeoplasmsHumansPancreasTriage

Identifiers

PMID37783684
PMCPMC10545767
OpenAlexW4387258416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.