Evidence map›Paper›PMID 37782798›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Molecular determinants for cold adaptation in an Antarctic Na

Gaddiel Galarza-Muñoz, Sonia I Soto-Morales, Song Jiao, Miguel Holmgren, Joshua J C Rosenthal

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gaddiel Galarza-MuñozInstitute of Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00901.ORCID 0009-0008-2814-8783
Sonia I Soto-MoralesInstitute of Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00901.
Song JiaoNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0003-0496-6454
Miguel HolmgrenNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0001-8285-4242
Joshua J C RosenthalInstitute of Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00901.ORCID 0000-0001-8139-9364
University of Puerto Rico, Medical Sciences Campus · PRNational Institute of Neurological Disorders and Stroke · US

Funding

SUPPLEMENT FOR RENOVATION OF ANIMAL FACILITIES AT INSTITUTE OF NEUROBIOLOGYG12RR003051 · NCRR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ESPINO, ANA M · 1986 to 2011
$28.1M
SPECIALIZED PROGRAMS IN CELLULAR/ MOLECULAR NEUROBIOLOGYU54NS039405 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FRONTERA, WALTER R. · 1999 to 2011
$12.9M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Regulation of the Na/K Pump by RNA EditingR01NS064259 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ROSENTHAL, JOSHUA J.C. · 2010 to 2014
$1.5M
NCRR NIH HHS G12 RR003051NIMHD NIH HHS G12 MD007600NINDS NIH HHS R01 NS064259NINDS NIH HHS U54 NS039405
6 · The paper itself

Abstract

Enzymes from ectotherms living in chronically cold environments have evolved structural innovations to overcome the effects of temperature on catalysis. Cold adaptation of soluble enzymes is driven by changes within their primary structure or the aqueous milieu. For membrane-embedded enzymes, like the Na

Indexed as

Lipid BilayersOctopodiformesSodium-Potassium-Exchanging ATPaseAcclimatizationAmino AcidsAnimalsAntarctic RegionsAmino AcidsLipid BilayersSodium-Potassium-Exchanging ATPaseAntarcticaion homeostasisNa+/K+-ATPaseoctopustemperature adaptation

Identifiers

PMID37782798
PMCPMC10576127
OpenAlexW4387245818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.