Evidence map›Paper›PMID 37782415›Full record

ArticleAnnals of surgical oncology2024

Association of Neighborhood Disadvantage with Short- and Long-Term Outcomes After Pancreatectomy for Pancreatic Ductal Adenocarcinoma.

Clayton T Marcinak, Corinne E Praska, Roberto J Vidri, Amy K Taylor, John K Krebsbach, Kaleem S Ahmed, Noelle K LoConte, Patrick R Varley, Majid Afshar, Sharon M Weber and 6 more

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Clayton T MarcinakDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Corinne E PraskaDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Roberto J VidriDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Amy K TaylorDivision of Hematology, Oncology, and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
John K KrebsbachSchool of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Kaleem S AhmedDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Noelle K LoConteDivision of Hematology, Oncology, and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Patrick R VarleyDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Majid AfsharDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Sharon M WeberDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Daniel E AbbottDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Jomol MathewDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Muhammed MurtazaDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Mark E BurkardDivision of Hematology, Oncology, and Palliative Care, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Matthew M ChurpekDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Syed Nabeel ZafarDivision of Surgical Oncology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. zafars@surgery.wisc.edu.ORCID http://orcid.org/0000-0003-3843-9687

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
Using causal machine learning for personalized treatment recommendations in critically ill patientsR01HL157262 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Matthew Michael Churpek · 2021 to 2026
$3.1M
Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancerR01CA234904 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E, WEAVER, BETH A · 2019 to 2023
$2.7M
Individualized monitoring of treatment response and resistance in patients with metastatic melanomaR01CA223481 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MURTAZA, MUHAMMED · 2018 to 2022
$2.0M
Pre-analytical factors affecting ctDNA analysis in early and locally advanced breast cancerU01CA243078 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MURTAZA, MUHAMMED · 2019 to 2023
$1.9M
Mechanisms of Plk1 at the mitotic centromereR01GM141068 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WEAVER, BETH A · 2021 to 2024
$1.2M
Treatment monitoring in early and locally advanced breast cancer using circulating tumor DNA analysisUH3CA234306 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Muhammed Murtaza · 2024 to 2026
$902k
Treatment monitoring in early and locally advanced breast cancer using circulating tumor DNA analysisUH2CA234306 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MURTAZA, MUHAMMED · 2020 to 2020
$309k
NCI NIH HHS P30 CA014520NCI NIH HHS P30 CA014520-48S4NCI NIH HHS R01 CA223481NCI NIH HHS R01 CA234904NCI NIH HHS U01 CA243078NCI NIH HHS UH2 CA234306NCI NIH HHS UH3 CA234306NHGRI NIH HHS T32 HG002760NHLBI NIH HHS R01 HL157262NIGMS NIH HHS R01 GM141068
6 · The paper itself

Abstract

backgroundWhile lower socioeconomic status has been shown to correlate with worse outcomes in cancer care, data correlating neighborhood-level metrics with outcomes are scarce. We aim to explore the association between neighborhood disadvantage and both short- and long-term postoperative outcomes in patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND

methodsWe retrospectively analyzed 243 patients who underwent resection for PDAC at a single institution between 1 January 2010 and 15 September 2021. To measure neighborhood disadvantage, the cohort was divided into tertiles by Area Deprivation Index (ADI). Short-term outcomes of interest were minor complications, major complications, unplanned readmission within 30 days, prolonged hospitalization, and delayed gastric emptying (DGE). The long-term outcome of interest was overall survival. Logistic regression was used to test short-term outcomes; Cox proportional hazards models and Kaplan-Meier method were used for long-term outcomes.

resultsThe median ADI of the cohort was 49 (IQR 32-64.5). On adjusted analysis, the high-ADI group demonstrated greater odds of suffering a major complication (odds ratio [OR], 2.78; 95% confidence interval [CI], 1.26-6.40; p = 0.01) and of an unplanned readmission (OR, 3.09; 95% CI, 1.16-9.28; p = 0.03) compared with the low-ADI group. There were no significant differences between groups in the odds of minor complications, prolonged hospitalization, or DGE (all p > 0.05). High ADI did not confer an increased hazard of death (p = 0.63).

conclusionsWe found that worse neighborhood disadvantage is associated with a higher risk of major complication and unplanned readmission after pancreatectomy for PDAC.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsHumansNeighborhood CharacteristicsPancreatectomyRetrospective Studies

Identifiers

PMID37782415
PMCPMC11170687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.