Evidence map›Paper›PMID 37781956›Full record

ArticleJournal of surgical oncology2023

Association of Medicaid expansion with 2-year survival and time to treatment initiation in gastrointestinal cancer patients: A National Cancer Database study.

Erin M Mobley, Guanming Chen, Jie Xu, Lauren Edgar, Keouna Pather, Meghan C Daly, Ziad T Awad, Alexander S Parker, Zhigang Xie, Ryan Suk and 2 more

Abstract read
In one paragraph

Article in Journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erin M MobleyDivision of General Surgery and Surgical Oncology, Department of Surgery, College of Medicine, University of Florida, Jacksonville, Florida, USA.ORCID http://orcid.org/0000-0002-6278-6593
Guanming ChenDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Jie XuDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Lauren EdgarDivision of General Surgery and Surgical Oncology, Department of Surgery, College of Medicine, University of Florida, Jacksonville, Florida, USA.
Keouna PatherDivision of General Surgery and Surgical Oncology, Department of Surgery, College of Medicine, University of Florida, Jacksonville, Florida, USA.
Meghan C DalyDivision of General Surgery and Surgical Oncology, Department of Surgery, College of Medicine, University of Florida, Jacksonville, Florida, USA.
Ziad T AwadDivision of General Surgery and Surgical Oncology, Department of Surgery, College of Medicine, University of Florida, Jacksonville, Florida, USA.
Alexander S ParkerCollege of Medicine, University of Florida, Jacksonville, Florida, USA.
Zhigang XieDepartment of Public Health, University of North Florida, Jacksonville, Florida, USA.
Ryan SukDepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Simon MathewsDivision of Gastroenterology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Young-Rock HongDepartment of Health Services Research, Management, and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)R33AG056540 · NIA · UNIVERSITY OF FLORIDA · PI ANTON, STEPHEN D · 2017 to 2021
$3.8M
NCI NIH HHS L40 CA253827NCI NIH HHS P30 CA086862NIA NIH HHS 5R33AG056540NIA NIH HHS P30 AG028740NIA NIH HHS R33 AG056540
6 · The paper itself

Abstract

introductionWe evaluated whether Medicaid expansion (ME) was associated with improved 2-year survival and time to treatment initiation (TTI) among patients with gastrointestinal (GI) cancer.

methodsGI cancer patients diagnosed 40-64 years were queried from the National Cancer Database. Those diagnosed from 2010 to 2012 were considered pre-expansion; those diagnosed from 2014 to 2016 were considered post-expansion. Cox models estimated hazard ratios and 95% confidence intervals (CIs) for 2-year overall survival. Generalized estimating equations (GEE) estimated odds ratios (OR) and 95% CI of TTI within 30- and 90 days. Multivariable Difference-in-Difference models were used to compare expansion/nonexpansion cohorts pre-/post-expansion, adjusting for patient, clinical, and hospital factors.

results377,063 patients were included. No significant difference in 2-year survival was demonstrated across ME and non-ME states overall or in site-based subgroup analysis. In stage-based subgroup analysis, 2-year survival significantly improved among stage II cancer, with an 8% decreased hazard of death at 2 years (0.92; 0.87-0.97). Those with stage IV had a 4% increased hazard of death at 2 years (1.04; 1.01-1.07). Multivariable GEE models showed increased TTI within 30 days (1.12; 1.09-1.16) and 90 days (1.22; 1.17-1.27). Site-based subgroup analyses indicated increased likelihood of TTI within 30 and 90 days among colon, liver, pancreas, rectum, and stomach cancers, by 30 days for small intestinal cancer, and by 90 days for esophageal cancer. In subgroup analyses, all stages experienced improved odds of TTI within 30 and 90 days.

conclusionME was not associated with significant improvement in 2-year survival for those with GI cancer. Although TTI increased after ME for both cohorts, the 30- and 90-day odds of TTI was higher for those from ME compared with non-ME states. Our findings add to growing evidence of associations with ME for those diagnosed with GI cancer.

Indexed as

Esophageal NeoplasmsGastrointestinal NeoplasmsHumansMedicaidProportional Hazards ModelsTime-to-TreatmentUnited Statesgastrointestinal neoplasmsMedicaidsurvivaltime-to-treatment

Identifiers

PMID37781956
PMCPMC11457958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.