Evidence map›Paper›PMID 37781907›Full record

ArticleMolecular pharmaceutics2023

Enhancement of Anti-inflammatory Effects of Synthetic High-Density Lipoproteins by Incorporation of Anionic Lipids.

Minzhi Yu, Kristen Hong Dorsey, Troy Halseth, Anna Schwendeman

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Minzhi YuDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Kristen Hong DorseyDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Troy HalsethBiointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Anna SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-8023-8080
University of Michigan · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
Synthetic HDL_a potential sepsis therapyR01GM113832 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN, SCHWENDEMAN, ANNA · 2015 to 2019
$3.0M
Training Program in Translational Cardiovascular Research and EntrepreneurshipT32HL125242 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MICHELE, DANIEL E · 2015 to 2024
$1.9M
Relative adrenal insufficiency as a risk factor and an endotype for sepsisR35GM141478 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN · 2021 to 2025
$1.9M
Optimization of synthetic HDL nanoparticles for treatment Niemann-Pick Type CR21NS111191 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, ANNA · 2019 to 2019
$429k
NHLBI NIH HHS T32 HL125242NIGMS NIH HHS R01 GM113832NIGMS NIH HHS R35 GM141478NIGMS NIH HHS T32 GM007767NINDS NIH HHS R21 NS111191
6 · The paper itself

Abstract

Phosphatidylserine (PS) is an anionic phospholipid component in endogenous high-density lipoprotein (HDL). With the intrinsic anti-inflammatory effects of PS and the correlation between PS content and HDL functions, it was hypothesized that incorporating PS would enhance the therapeutic effects of HDL mimetic particles. To test this hypothesis, a series of synthetic high-density lipoproteins (sHDLs) were prepared with an apolipoprotein A-I (ApoA-1) mimetic peptide, 1-palmitoyl-2-oleoyl-

Indexed as

Endothelial CellsLipoproteins, HDLAnti-Inflammatory AgentsCholesterolPhospholipidsAnti-Inflammatory AgentsCholesterolLipoproteins, HDLPhospholipidsanti-inflammationphosphatidylserinereverse cholesterol transportsynthetic high-density lipoproteins

Identifiers

PMID37781907
PMCPMC10916337
OpenAlexW4387241453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.